The Dallas Cowboys and New York Giants play on Sunday, Sept. 13, at the Giants' MetLife Stadium in a game on the NFL Week 1 schedule.
Which team will win the NFL Week 1 Sunday Night Football game?
Check out these NFL Week 1 picks and NFL Week 1 predictions for the game, which can be seen at 5:20 p.m. MST on NBC (stream with Peacock).
The Cowboys are a 3-point favorite over the Giants in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.
Dallas is -160 on the moneyline, while New York is +130. The over/under (point total) is set at 48.5 points.
Watch Cowboys vs Giants on Peacock
The Arizona Republic: Giants 30, Cowboys 27
Jeremy Cluff writes: "The Cowboys are a 3-point road favorite in this game, but John Harbaugh will have his team ready in Week 1. Jaxson Dart will come up with some
big plays to help the Giants get the upset win at home."
Bookies.com: Bet the over in Giants vs Cowboys game
Bill Speros writes: "The NFL gifted NBC with a spectacular bookend to the season-opener on Wednesday night. Big Blue got its most-wanted coach in John Harbaugh. He's tasked Matt Nagy with overhauling the offense, led by QB Jaxson Dart, dishing the ball to a healthy Cam Skattebo and Malik Nabers. Dak Prescott and the Cowboys ripped off 9 straight wins over the Giants before losing last season's meaningless finale. While the Giants revamped their offensive this offseason, the Cowboys simply fine-tuned theirs. Big Blue carries at least a half-dozen new starters on defense. This one opens for both offenses in the 4th quarter."
Sports Betting Dime: Cowboys 31.7, Giants 29.3
The site's formula predicts the Cowboys will win the NFL Week 1 game against the Giants.
ESPN: Cowboys have a 57.2% chance to beat Giants
The site gives the Giants a 42.4% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Dimers: Cowboys 25, Giants 23
It writes: "After extensive simulations, our model gives the Cowboys a win probability of 58%, while the Giants have a win probability of 42%."
BetMGM: Bet the Cowboys to score more than 25.5 points vs Giants
Nick Hennion writes: "Based on the Giants’ defensive departures this offseason and their lack of success against Dallas last year, my Giants vs Cowboys prediction is the Cowboys Over 25.5 Points. Trading Dexter Lawrence leaves a massive absence on New York’s defense. The unit remains strong at edge rusher, but it’s mitigated here against a good Cowboys offensive line. It led to the team struggling immensely last year against a strong Cowboys offense."
NFL's highest paid players in 2026: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Cowboys vs Giants picks, predictions, odds for NFL Week 1 game
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