Who will win NFL Week 3 games on Sept. 27?
Look at The Arizona Republic's score prediction for every game on the NFL Week 3 schedule today.
The games include the Los Angeles Chargers at Buffalo Bills, Carolina Panthers at Cleveland Browns, New York Jets at Detroit Lions, Houston Texans at Indianapolis Colts, New England Patriots at Jacksonville Jaguars, Kansas City Chiefs at Miami Dolphins, Tennessee Titans at New York Giants, Cincinnati Bengals at Pittsburgh Steelers, Seattle Seahawks at Washington Commanders, Arizona Cardinals at San Francisco 49ers, Minnesota Vikings at Tampa Bay Buccaneers, Las Vegas Raiders at New Orleans Saints, Baltimore Ravens vs Dallas Cowboys in Brazil and Los Angeles Rams at Denver Broncos on Sunday Night Football.
Click on each game for NFL Week 3 picks, NFL Week 3 predictions, NFL Week 3 win probabilities and NFL Week 3 odds for that game.
All times MST.
NFL Week 3 predictions: Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | Win probabilities
Watch Sunday's NFL games on FUBO (free trial)
Sunday early NFL game predictions, Sept. 27
Los Angeles Chargers at Buffalo Bills, 10 a.m. FOX (stream with FUBO)
Score prediction: Bills 33, Chargers 17
Carolina Panthers at Cleveland Browns, 10 a.m., FOX (stream with FUBO)
Score prediction: Panthers 28, Browns 17
New York Jets at Detroit Lions, 10 a.m., FOX (stream with FUBO)
Score prediction: Lions 30, Jets 20
Houston Texans at Indianapolis Colts, 10 a.m., CBS (stream with FUBO)
Score prediction: Texans 23, Colts 20
New England Patriots at Jacksonville Jaguars, 10 a.m., CBS (stream with FUBO)
Score prediction: Patriots 31, Jaguars 27
Kansas City Chiefs at Miami Dolphins, 10 a.m., CBS (stream with FUBO)
Score prediction: Chiefs 30, Dolphins 16
Tennessee Titans at New York Giants, 10 a.m., CBS (stream with FUBO)
Score prediction: Giants 27, Titans 20
Cincinnati Bengals at Pittsburgh Steelers, 10 a.m., CBS (stream with FUBO)
Score prediction: Bengals 24, Steelers 20
Seattle Seahawks at Washington Commanders, 10 a.m., FOX (stream with FUBO)
Score prediction: Seahawks 28, Commanders 17
NFL Week 3 picks: Falcons at Packers | Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | The Republic's predictions
Sunday late NFL game predictions, Sept. 27
Arizona Cardinals at San Francisco 49ers, 1:05 p.m., FOX (stream with FUBO)
Score prediction: 49ers 31, Cardinals 17
Minnesota Vikings at Tampa Bay Buccaneers, 1:05 p.m., FOX (stream with FUBO)
Prediction: Vikings 24, Buccaneers 16
Las Vegas Raiders at New Orleans Saints, 1:25 p.m., CBS (stream with FUBO)
Score prediction: Saints 24, Raiders 23
NFL Week 3 odds: Falcons at Packers | Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | Point spreads, moneylines, totals for betting
NFL International game prediction, Sept. 27
Baltimore Ravens at Dallas Cowboys (Rio de Janeiro, Brazil), 1:25 p.m., CBS (stream with FUBO)
Score prediction: Ravens 31, Cowboys 27
Sunday Night Football prediction, Sept. 27
Los Angeles Rams at Denver Broncos, 5:20 p.m., NBC (stream with Peacock)
Score prediction: Rams 27, Broncos 24
NFL's highest paid players in 2026: Quarterbacks | Running backs | Wide receivers | Tight ends | O-linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don't miss a thing.
This article originally appeared on Arizona Republic: NFL Week 3 predictions, picks for who will win every game on Sunday
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
