The Denver Broncos and Kansas City Chiefs play on Monday, Sept. 14, at the Chiefs' Arrowhead Stadium in a game on the NFL Week 1 schedule.
Which team will win the NFL Week 1 Monday Night Football game?
Check out these NFL Week 1 picks and NFL Week 1 predictions for the game, which can be seen at 5:15 p.m. MST on ESPN and ABC (stream with FUBO).
The Chiefs are a 2.5-point favorite over the Broncos in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.
Kansas City is -145 on the moneyline, while Denver is +120. The over/under (point total) is set at 43.5 points.
Watch Broncos vs Chiefs on FUBO (free trial)
The Arizona Republic: Chiefs 27, Broncos 24
Jeremy Cluff writes: "Sean Payton holds a 7-4 coaching record against Andy Reid, but Reid has had an entire offseason to get ready for this
game. This one could be very interesting."
Bookies.com: Bet the Broncos with the points vs Chiefs
Bill Speros writes: "The NFL steps back in time — all the way to 2024. Patrick, Brittany, Travis and Taylor capture the spotlight in prime time as ESPN enters 'ludicrous speed' in hyping its Super Bowl 61 telecast. A healthy Patrick Mahomes won't have to do all the heavy lifting and running, with Super Bowl MVP Kenneth Walker carrying the ball 25 times a night. Look for Travis Kelce to play a lesser role this season. But who cares as long as his new bride cheers on from the luxury box. The Broncos ended KC's nine-year reign in the AFC West but snowed out in the AFC Championship by the Patriots and an injury to Bo Nix. The Broncos defense may be the NFL's best this season. And it shows on this night."
Sports Betting Dime: Broncos 18.1, Chiefs 11.4
The site's formula predicts that the Broncos will win the NFL Week 1 game against the Chiefs.
ESPN: Chiefs have a 58.5% chance to beat Broncos
The site gives the Broncos a 41.2% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Dimers: Chiefs 22, Broncos 20
It writes: "After extensive simulations, our model gives the Broncos a win probability of 43%, while the Chiefs have a win probability of 57%."
BetMGM: Bet the Chiefs to cover vs Broncos
Nick Hennion writes: "Based on the Broncos’ inexperience against good offenses and Kansas City’s presumed ability to run the ball, my Chiefs vs Broncos prediction is the Chiefs Spread (-3, -105). Confidence here is relatively low given the unknowns surrounding Patrick Mahomes’ health. Additionally, it’s difficult to evaluate this game in a nutshell given the 2025 meetings. Zero stock should be placed into Denver’s defensive performance in Week 17. Kansas City started Chris Oladokun at quarterback against an elite unit that sold out to stop the run."
NFL's highest paid players in 2026: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Broncos vs Chiefs picks, predictions, odds for NFL Week 1 game
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