The Florida Gators and Missouri Tigers play on Saturday, Oct. 3, 2026, at Memorial Stadium in Columbia, Missouri, in a game on the college football Week 5 schedule.
Which team will win the college football Week 5 game?
Check out these college football Week 5 picks and college football Week 5 predictions for the game, which can be seen at 12:30 p.m. MST on ABC (stream with FUBO).
Florida is a 5-point favorite over Missouri in college football Week 5 odds for the game, according to BetMGM Sportsbook.
The Gators are -210 on the moneyline, while the Tigers are +175. The over/under (point total) for the game is set at 56.5 points.
Watch Florida vs Missouri on FUBO (free trial)
Sporting News: Florida 31, Missouri 24
Bill Bender writes: "How will the Gators handle the success of last week's victory
against Ole Miss? The Tigers are coming off a one-score loss, and Missouri is 3-3 S/U as a home underdog since 2023 under Eli Drinkwitz. Will the Tigers be able to slow a Florida rushing attack that averages 260 yards per game with Jadan Baugh, who has 600 yards and 11 TDs? Three of the last four meetings have been one-score games."
Bookies.com: Bet Florida to cover vs Missouri
Bill Speros writes: "The SEC Marquee Game of the Week sends the orange-hot Florida Gators to the other Columbia. The winner here remains alive in the chase for a berth in the SEC title game and/or a CFP spot. Florida pasted Ole Miss 52-28 in The Swamp on Saturday, that program's most decisive and impactful victory since Tim Tebow and Aaron Hernandez roamed Gainesville. The Gators now face the same big letdown factor that Ole Miss failed to master in the first half after its win over LSU. Missouri allowed 499 yards of total offense — and 14 points in the fourth quarter — in its loss to Mississippi State. Florida's running game is its strength, and Aaron Philo can sling it, but the Gators remain mistake-prone. Our model gives Florida just a 0.4-point edge, so Missouri is the value play on paper. We'll still take the Gators: this is the week they prove they're for real, warts and all."
Dimers.com: Florida 31, Missouri 25
It writes: "After extensive simulations, our model gives Florida a win probability of 67%, while Missouri has a win probability of 33%."
ESPN: Florida has a 70.2% chance to defeat Missouri
The site gives the Tigers a 29.8% shot at winning the college football Week 5 game.
Sports Betting Dime: Florida 34.1, Missouri 28.4
The site's formula predicts that the Gators will beat the Tigers in the Week 5 college football game.
Gators Wire: Florida 45, Missouri 27
Adam Dubbin writes: "Jadan Baugh will have another 100-plus-yard game, the defense will continue to coalesce and the special teams will play their role once again as well. Expect Sumrall and Co. to roll to victory in this one."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Florida vs Missouri picks, predictions, odds for Week 5 game Saturday
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