The LSU Tigers and Kentucky Wildcats play on Saturday, Oct. 10, 2026, at Kroger Field in Lexington, Kentucky, in a game on the college football Week 6 schedule.
Which team will win the college football Week 6 game?
Check out these college football Week 6 picks and college football Week 6 predictions for the game, which can be seen at 4 p.m. MST on ESPN (stream with FUBO).
LSU is a 9.5-point favorite over Kentucky in college football Week 6 odds for the game, according to BetMGM Sportsbook.
The Tigers are -350 on the moneyline, while the Wildcats are +275. The over/under (point total) for the game is set at 54.5 points.
Watch LSU vs Kentucky on FUBO (free trial)
Sporting News: LSU 38, Kentucky 21
Bill Bender writes: "This is another fun SEC prime-time game given the Wildcats are off
to a hot start under Will Stein. Jason Patterson (355 yards, 3 TDs) and CJ Baxter (361 yards, 6 TDs) have kept the rushing attack moving – and they'll need turnovers to slow down an LSU offense that ranks third in the FBS with 547.8 total yards per game. Kentucky has won the last two meetings in Lexington."
Bookies.com: Bet Kentucky with the points vs LSU
Bill Speros writes: "Kroger Field has become the sneaky-toughest trap in the SEC. This is where SEC Championship Game hopes go to die. Lane Kiffin and LSU need to win out for any hope of a title game or playoff berth, but his Tigers remain unproven on the road in this league. Our model sits on the line here, pegging LSU to win by 10.8 points. Kentucky stayed alive in the SEC by erasing a 17-0 deficit before clipping South Carolina 35-34 on Saturday. And we've seen too many games end in despair for favored road teams in Lexington. Take the Wildcats as big home dogs."
Dimers.com: LSU 31, Kentucky 24
It writes: "The numbers give LSU a win probability of 72.5%, while Kentucky has a win probability of 27.5%."
ESPN: LSU has a 75.4% chance to defeat Kentucky
The site gives the Wildcats a 24.6% shot at winning the college football Week 6 game.
Sports Betting Dime: LSU 30, Kentucky 22.4
The site's formula predicts that the Tigers will beat the Wildcats in the Week 6 college football game.
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don't miss a thing.
This article originally appeared on Arizona Republic: LSU vs Kentucky picks, predictions, odds for Week 6 game Saturday
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
