The New Orleans Saints and Detroit Lions play on Sunday, Sept. 13, at the Lions' Ford Field in a game on the NFL Week 1 schedule.
Which team will win the NFL Week 1 game?
Check out these NFL Week 1 picks and NFL Week 1 predictions for the game, which can be seem at 10 a.m. MST on FOX (stream with FUBO).
The Lions are a 7-point favorite over the Saints in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook
.Detroit is -300 on the moneyline, while New Orleans is +250. The over/under (point total) is set at 50.5 points.
Watch Saints vs Lions on FUBO (free trial)
The Arizona Republic: Lions 33, Saints 20
Jeremy Cluff writes: "This Lions team is kind of flying under the radar in preseason Super Bowl odds, but Jared Goff and company still have firepower on offense, as the Saints will find
out."
Bookies.com: Bet the Saints with the points vs Lions
Bill Speros writes: "The Saints-Lions is one of two last-place matchups in Week 1. The other is the Jets-Titans. The Saints roll into Ford Field with NFL sophomore Tyler Shough as their starting QB. The offense added RB Travis Etienne and first-round WR Jordyn Tyson. After a disappointing 9-8 finish, the Lions boosted their defensive core with LB Devin White, late of Tampa Bay. The Lions have a new offensive coordinator in Drew Petzing. That means some offensive frustration and misfires early in the season. The Lions held the best record ATS combined in the NFL from 2022-24 before falling to 8-9 last season. The Saints defense keeps it close, here, as well."
Sports Betting Dime: Lions 25.8, Saints 16.6
The site's formula predicts that the Lions will win the NFL Week 1 game against the Saints.
ESPN: Lions have a 71.9% chance to beat Saints
The site gives the Saints a 27.9% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Dimers: Lions 28, Saints 21
It writes: "After extensive simulations, our model gives the Saints a win probability of 27%, while the Lions have a win probability of 73%."
BetMGM: Bet the Lions to score more than 30.5 points vs Saints
Nick Hennion writes: "Based on New Orleans’ poor defensive record against good offenses last season and Detroit’s success against good units, my Lions vs Saints prediction is the Lions Over 30.5 Points. Three opponents cleared this number against the ‘25 Saints: the Rams, Bills and Seahawks. It’s my belief Detroit shares more traits with those teams than the 14 that failed to crack 30 points. Los Angeles and Buffalo scored 34 and 31, respectively, while the Seahawks blitzed New Orleans for 44. The latter matchup included a Tory Horton punt return touchdown by Seattle."
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Saints vs Lions picks, predictions, odds for NFL Week 1 game
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