The Buffalo Bills and Houston Texans play on Sunday, Sept. 13, at the Texans' NRG Stadium in a game on the NFL Week 1 schedule.
Which team will win the NFL Week 1 game?
Check out these NFL Week 1 picks and NFL Week 1 predictions for the game, which can be seen at 10 a.m. MST on CBS (stream with FUBO).
The Bills are a 1-point favorite over the Texans in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook
.Buffalo is -118 on the moneyline, while Houston is -102. The over/under (point total) is set at 44.5 points.
Watch Bills vs Texans on FUBO (free trial)
The Arizona Republic: Bills 23, Texans 20
Jeremy Cluff writes: "Could this be the game of the week? It had the smallest point spread in early odds, with the Bills favored by a point on the road at Houston. Josh Allen will deliver
late."
Bookies.com: Bet the Texans on the moneyline vs Bills
Bill Speros writes: "Multiple sharp bettors - not to mention plain old fans - see this as a potential AFC Championship Game preview. According to Adam Bjorn of Betcris AZ and Prime Sports, his book has seen significant sharp money on both teams to reach and/or win the Super Bowl. The Bills remain a perennial favorite of recreational bettors. But the early sharp money on them this season could be a tell that Josh Allen finally gets to the Super Bowl this season. The AFC South champion Texans self-immolated in the playoffs against New England in January. C.J. Stroud's offense remains stacked. Houston's ferocious defense ranks atop the AFC. The Texans wait until after the New Year to disappoint. They come out bucking, flipping and spinning this year. You'd better hold on, Josh."
Sports Betting Dime: Bills 19.2, Texans 19.1
The site's formula predicts that the Bills will win the NFL Week 1 game against the Texans.
ESPN: Bills have a 53.5% chance to beat Texans
The site gives the Texans a 46.1% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Dimers: Bills 23, Texans 21
It writes: "After extensive simulations, our model gives the Bills a win probability of 57%, while the Texans have a win probability of 43%."
BetMGM: Take the Texans on the moneyline vs Bills
Nick Hennion writes: "Based on the Texans’ defensive advantages over a normally strong Bills offense and Buffalo’s lackluster defensive record, my Texans vs Bills prediction is the Texans Moneyline (+100). When these teams met in Week 12 last year, Buffalo’s offense struggled immensely. For the entire 2025 regular season, Buffalo recorded the following advanced metrics: +0.145 EPA per play and 48.2% success rate, including 50.5% dropback success rate."
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Bills vs Texans picks, predictions, odds for NFL Week 1 game
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