The Indiana Hoosiers and Nebraska Cornhuskers play on Saturday, Oct. 10, 2026, at Memorial Stadium in Lincoln, Nebraska, in a game on the college football Week 6 schedule.
Which team will win the college football Week 6 game?
Check out these college football Week 6 picks and college football Week 6 predictions for the game, which can be seen at 9 a.m. MST on FOX (stream with FUBO).
Indiana is a 7.5-point favorite over Nebraska in college football Week 6 odds for the game, according to BetMGM Sportsbook.
The Hoosiers are -300 on the moneyline, while the Cornhuskers are +240. The over/under (point total) for the game is set at 52.5 points.
Watch Indiana vs Nebraska on FUBO (free trial)
Sporting News: Indiana 31, Nebraska 20
Bill Bender writes: "This could turn into a defensive struggle —
and the line dropped a point. The Huskers are second in the FBS with a 21.3% defensive third-down percentage. The Hoosiers are No. 14 with a 26.9% conversion rate on defense. It should be a charged atmosphere. Both teams have well-balanced rushing attacks, too. Can Nebraska finally break a streak of 30 straight losses to AP Top 25 teams? Indiana won the last meeting 56-7 in 2024."
Bookies.com: Bet Nebraska with the points vs Indiana
Bill Speros writes: "Fox's Big Noon Kickoff graces Lincoln with its presence. Our model has Indiana winning by 7.7 points, so Nebraska offers solid value as a home dog with this number popping to 9.5 early Sunday after opening at 8.5. Last season, the Hoosiers completed perhaps the best season in the history of college football. But their 16-0 record wilted to 7-5 ATS (4 games weren't posted). IU has continued that trend this fall, finally grabbing its first cover in five games Saturday at Rutgers. Nebraska, meanwhile, is 4-1 ATS and ranked No. 15. Memorial Stadium on a pristine fall afternoon for a top-15 matchup is no tune-up. Ride this trend until further notice."
Dimers.com: Indiana 30, Nebraska 23
It writes: "The numbers give Indiana a win probability of 74.5%, while Nebraska has a win probability of 25.5%."
ESPN: Indiana has a 69.2% chance to defeat Nebraska
The site gives the Cornhuskers a 30.8% shot at winning the college football Week 6 game.
Sports Betting Dime: Indiana 25.8, Nebraska 24.9
The site's formula predicts the Hoosiers will beat the Cornhuskers in the Week 6 college football game.
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Indiana vs Nebraska picks, predictions, odds for Week 6 game Saturday
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