The Big 12 football Week 6 schedule has some very intriguing games, with some very intriguing betting lines.
What do college football betting odds say about each Big 12 game this week, Week 6 of the 2026 regular season?
Who is favored in the Arizona vs West Virginia game? Who is the favorite in the Hawaii vs Arizona State game?
What do the odds say about Houston vs Kansas State, Iowa State vs BYU, Kansas vs Utah, and the other Big 12 college football games in Week 6?
Take a look at the point spread, moneyline and over/under for every game on the Week 6 Big 12 college football schedule, courtesy of BetMGM Sportsbook.
Big 12 football odds: Week 6 point spreads
- Iowa State (-10.5) at BYU (+10.5)
- UCF (+9) at Oklahoma State (-9)
- Arizona (-3.5) at West Virginia (+3.5)
- Houston (+2.5) at Kansas State (-2.5)
- Kansas (+15) at Utah (-15)
- Hawaii (+20.5) at Arizona State (-20.5)
Big 12 football odds: Week 6 moneylines
- Iowa State (+333) at BYU (-450)
- UCF (+290) at Oklahoma State (-375)
- Arizona (-165) at West Virginia (+135)
- Houston (+120) at Kansas State (-145)
- Kansas (+525) at Utah (-700)
- Hawaii (+950) at Arizona State (-1400)
Big 12 football odds: Week 6 over/unders (point totals)
- Iowa State at BYU: 48.5
- UCF at Oklahoma State: 53.5
- Arizona at West Virginia: 59.5
- Houston at Kansas State: 56.5
- Kansas at Utah: 51.5
- Hawaii at Arizona State: 51.5
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Big 12 football Week 6 odds, point spreads, moneylines, over/unders
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