The Arizona Cardinals play the Detroit Lions in a game on the NFL Week 5 schedule on Sunday, Oct. 11, 2026 at State Farm Stadium in Glendale, Arizona.
The Cardinals enter the game 1-3 overall. The Lions are 2-2.
What's the Arizona Cardinals vs Detroit Lions score?
Follow our live score updates today for the latest news, notes, highlights and analysis from the Week 5 NFL matchup
between the Cardinals and Lions.NFL Week 5 schedule today: Eagles vs Jaguars | Bengals vs Dolphins | Raiders vs Patriots | Vikings vs Saints | Browns vs Jets | Colts vs Steelers | Texans vs Titans | Giants vs Commanders | Bears vs Packers | Broncos vs Chargers | Lions vs Cardinals | 49ers vs Seahawks | Ravens vs Falcons | TV channels | Announcers | How to watch, stream games
on Sunday
Watch Cardinals vs Lions on FUBO (free trial)
What time is the Cardinals vs Lions game today?
The Detroit Lions vs Arizona Cardinals Week 5 NFL game is scheduled for 1:25 p.m. MST (4:25 p.m. ET) on Sunday, Oct. 11, 2026.
What channel is the Lions vs Cardinals game on Sunday?
The Arizona Cardinals vs Detroit Lions NFL Week 5 game today can be seen on TV on FOX.
How can I stream the Cardinals vs Lions game on Oct. 11?
The Detroit vs Arizona game in NFL Week 5 can be streamed on FUBO, which offers a free trial.
Click here to sign up for a free trial of FUBO
Who is announcing the Lions vs Cardinals NFL Week 5 game?
Kevin Kugler will have the play-by-play call of the Week 5 NFL game between the Arizona Cardinals and Detroit Lions today, with Daryl Johnston as the analyst.
Detroit Lions vs Arizona Cardinals prediction
The Arizona Republic predicts a 30-20 win for the Lions over the Cardinals in the NFL Week 5 Sunday football game.
Jeremy Cluff writes: "The Lions are 2-0 at home and 0-2 on the road, but we have a feeling that Jared Goff and Detroit's offense are going to get very comfortable at State Farm Stadium. Jacoby Brissett and Arizona will lose a fourth straight game."
NFL Week 5 predictions: Cowboys vs Buccaneers | Jaguars vs Eagles | Dolphins vs Bengals | Patriots vs Raiders | Saints vs Vikings | Jets vs Browns | Steelers vs Colts | Titans vs Texans | Commanders vs Giants | Packers vs Bears | Chargers vs Broncos | Cardinals vs Lions | Seahawks vs 49ers | Falcons vs Ravens | Rams vs Bills | Win probabilities
Arizona Cardinals vs Detroit Lions picks
Will the Lions or Cardinals win the game in NFL Week 5?
Bookies.com says to bet the Cardinals with the points against the Lions.
Sports Betting Dime's formula predicts a 34.5-28.4 win for the Lions over the Cardinals.
Dimers.com's final score prediction? Lions 29, Cardinals 24.
Detroit Lions vs Arizona Cardinals win probabilities
The Lions have a 68.9% chance to beat the Cardinals, according to ESPN.
The site gives the Cardinals a 30.8% shot at winning the NFL Week 5 game, with the remaining percentage accounting for a tie.

Cardinals vs Lions odds: What is the point spread Sunday?
According to BetMGM Sportsbook, the Lions are a 4.5-point favorite over the Cardinals in the NFL Week 5 game on Oct. 11.
NFL Week 5 picks: Buccaneers vs Cowboys | Eagles vs Jaguars | Bengals vs Dolphins | Raiders vs Patriots | Vikings vs Saints | Browns vs Jets | Colts vs Steelers | Texans vs Titans | Giants vs Commanders | Bears vs Packers | Broncos vs Chargers | Lions vs Cardinals | 49ers vs Seahawks | Ravens vs Falcons | Bills vs Rams | The Republic's predictions
Lions vs Cardinals odds: What is the moneyline on Oct. 11?
BetMGM Sportsbook lists Detroit as -235 on the moneyline for the NFL Week 5 game on Sunday. It has Arizona at +195.
Cardinals vs Lions odds: What is the over/under in NFL Week 5 game?
The point total for the Cardinals vs Lions Week 5 NFL game this week is listed at 54 points, per BetMGM Sportsbook.
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This article originally appeared on Arizona Republic: Detroit Lions vs Arizona Cardinals live score updates for NFL Week 5
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