The Cleveland Browns and Jacksonville Jaguars play Sunday, Sept. 13, at the Jaguars' EverBank Stadium in a game on the NFL Week 1 schedule.
Which team will win the NFL Week 1 game?
Check out these NFL Week
1 picks and NFL Week 1 predictions for the game, which can be seen at 10 a.m. MST on CBS (stream with FUBO).
The Jaguars are an 8-point favorite over the Browns in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.
Jacksonville is -400 on the moneyline, while Cleveland is +310. The over/under (point total) is set at 40.5 points.
Watch Browns vs Jaguars on FUBO (free trial)
The Arizona Republic: Jaguars 28, Browns 17
Jeremy Cluff writes: "How many times will the Jaguars' defense sack Deshaun Watson in this game? We're thinking Jacksonville's pressure will have a big impact in a big Week 1 win at home."
Bookies.com: Bet the under in Jaguars vs Browns game
Bill Speros writes: "The Browns remained poised to continue their decades-long run of mediocrity in 2026. They dealt all-universe defensive end Myles Garrett to the Rams. New head coach, former Ravens OC Todd Monken, gets to build this team from scratch. The Browns QB room serves as the NFL's 'Island of Misfit Toys' with QBs Shedeur Sanders and Deshaun Watson vying for the QB1 spot. The Jaguars finally gave Trevor Lawrence stability this offseason. CB/WR Travis Hunter lurks as a potential "Comeback Player Of The Year" candidate. Expect temperatures in 90s at kickoff, with unrelenting humidity. Just perfect for a team from Cleveland. This game offers the 2nd longest line of Week 1 — and for good reason. The Browns were a respectable 9-8 ATS last year. We'll roll with the under, the weather and general Week 1 offensive ineptitude."
Sports Betting Dime: Jaguars 23.4, Browns 8.2
The site's formula predicts the Jaguars will win the NFL Week 1 game against the Browns.
ESPN: Jaguars have a 77.3% chance to beat Browns
The site gives the Browns a 22.5% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Dimers: Jaguars 24, Browns 17
It writes: "After extensive simulations, our model gives the Browns a win probability of 23%, while the Jaguars have a win probability of 77%."
BetMGM: Bet the Browns to score less than 17.5 points
Nick Hennion writes: "Based on Cleveland’s offensive record against bad defenses and the Jaguars’ matchup edges on defense, my Jaguars vs Browns prediction is the Browns Under 17.5 Points. While Jacksonville profiles as a massive defensive regression candidate, I’ll be surprised if it comes in this game. The Browns offense, despite playing almost exclusively bad defenses last year, struggled to score. Cleveland set the floor with a -33.9% offensive DVOA rating, per FTN Fantasy."
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Browns vs Jaguars picks, predictions, odds for NFL Week 1 game
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