The Arizona Cardinals play the Los Angeles Chargers in a game on the NFL Week 1 schedule Sunday, Sept. 13, 2026.
Can the Cardinals upset the Chargers?
Follow our live score updates for the latest news, notes, highlights and analysis from the game, which is being played at SoFi Stadium in Inglewood, California.
The Cardinals are coming off a 3-14 season in 2025.
The Chargers went 11-6 in the regular season last year.
NFL Week 1 predictions: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos
vs Chiefs | Picks, win probabilities
Watch Cardinals vs Chargers on FUBO (free trial)
What time is the Cardinals vs Chargers game today?
The Los Angeles Chargers vs. Arizona Cardinals Week 1 NFL game is scheduled for 1:25 p.m. MST (4:25 p.m. ET) on Sunday, Sept. 13, 2026.
What channel is the Chargers vs Cardinals game on Sunday?
The Arizona Cardinals vs. Los Angeles Chargers NFL Week 1 game today can be seen on TV on CBS.
NFL Week 1 picks: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | The Republic's predictions
How can I stream the Cardinals vs Chargers game on Sept. 13?
The Los Angeles vs. Arizona game in NFL Week 1 can be streamed on FUBO, which offers a free trial.
Who is announcing the Chargers vs Cardinals NFL Week 1 game?
Kevin Harlan will have the play-by-play call of the Week 1 NFL game between the Arizona Cardinals and Los Angeles Chargers today, with Trent Green as the analyst.
NFL Week 1 odds: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | Point spreads, moneylines, over/unders
Arizona Cardinals vs Los Angeles Chargers prediction
The Arizona Republic is predicting a 30-21 win for the Chargers over the Cardinals in the NFL Week 1 Sunday football game.
Jeremy Cluff writes: "The Mike LaFleur era begins with a tough test against the Chargers. Arizona is the biggest underdog of the week. Can the Cardinals just keep it close?"
Los Angeles Chargers vs Arizona Cardinals picks
Will the Chargers or Cardinals win the game in NFL Week 1?
Bookies.com says to bet the under in Chargers vs Cardinals game.
Sports Betting Dime's formula predicts a 26.4-13.1 win for the Chargers over the Cardinals.
Dimers.com's final score prediction? Chargers 27, Cardinals 17.
BetMGM is taking the Cardinals with the points against the Chargers.
Arizona Cardinals vs Los Angeles Chargers win probabilities
The Chargers have an 80.8% chance to beat the Cardinals on Sunday, according to ESPN.
The site gives the Cardinals a 19.1% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Chargers vs Cardinals odds: What is the point spread Sunday?
According to BetMGM Sportsbook, the Chargers are a 9-point favorite over the Cardinals in the NFL Week 1 game on Sept. 13.
Cardinals vs Chargers odds: What is the moneyline on Sept. 13?
BetMGM Sportsbook lists Los Angeles as -500 on the moneyline for the NFL Week 1 game on Sunday. It has Arizona at +380.
Chargers vs Cardinals odds: What is the over/under in NFL Week 1 game?
The point total for the Chargers vs Cardinals Week 1 NFL game this week is listed at 47 1/2 points, per BetMGM Sportsbook.
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This article originally appeared on Arizona Republic: Cardinals vs Chargers score updates from NFL Week 1 game today
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