The NFL Week 1 schedule features some very intriguing season-opening games.
And some very interesting betting lines for those games.
What do NFL betting odds say about each game this week, the first week of the 2026 NFL regular season?
Who is favored in the season-opening game between the New England Patriots and Seattle Seahawks? What about the Australia game between the San Francisco 49ers and Los Angeles Rams? What do the odds say about the Dallas Cowboys vs. New York Giants Sunday Night Football showdown and the Denver Broncos vs. Kansas City Chiefs matchup on Monday Night Football?
Take a look at the point spread, moneyline, and over/under for every game on the Week 1 NFL schedule, courtesy of BetMGM Sportsbook.
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NFL Week 1 odds: Point spreads
- New England Patriots (+3.5) at Seattle Seahawks (-3.5)
- San Francisco 49ers (+3.5) vs Los Angeles Rams (-3.5)
- Chicago Bears (-3) at Carolina Panthers (+3)
- Tampa Bay Buccaneers (+3.5) at Cincinnati Bengals (-3.5)
- New Orleans Saints (+7) at Detroit Lions (-7)
- Buffalo Bills (-1) vs Houston Texans (+1)
- Baltimore Ravens (-3.5) vs Indianapolis Colts (+3.5)
- Cleveland Browns (+8) vs Jacksonville Jaguars (-8)
- Atlanta Falcons (+3) vs Pittsburgh Steelers (-3)
- New York Jets (+1.5) vs Tennessee Titans (-1.5)
- Arizona Cardinals (+10.5) at Los Angeles Chargers (-10.5)
- Miami Dolphins (+3.5) at Las Vegas Raiders (-3.5)
- Green Bay Packers (+1.5) vs Minnesota Vikings (-1.5)
- Washington Commanders (+4.5) vs Philadelphia Eagles (-4.5)
- Dallas Cowboys (-3) at New York Giants (+3)
- Denver Broncos (+2.5) at Kansas City Chiefs (-2.5)
NFL Week 1 odds: Moneylines
- New England Patriots (+165) at Seattle Seahawks (-200)
- San Francisco 49ers (+165) vs Los Angeles Rams (-210)
- Chicago Bears (-160) at Carolina Panthers (+130)
- Tampa Bay Buccaneers (+165) at Cincinnati Bengals (-200)
- New Orleans Saints (+260) at Detroit Lions (-325)
- Buffalo Bills (-118) vs Houston Texans (-102)
- Baltimore Ravens (-185) vs Indianapolis Colts (+150)
- Cleveland Browns (+310) vs Jacksonville Jaguars (-400)
- Atlanta Falcons (+140) vs Pittsburgh Steelers (-165)
- New York Jets (+110) vs Tennessee Titans (-130)
- Arizona Cardinals (+425) at Los Angeles Chargers (-550)
- Miami Dolphins (+160) at Las Vegas Raiders (-200)
- Green Bay Packers (+100) vs Minnesota Vikings (-120)
- Washington Commanders (+185) vs Philadelphia Eagles (-225)
- Dallas Cowboys (-150) at New York Giants (+125)
- Denver Broncos (+120) at Kansas City Chiefs (-145)
NFL Week 1 odds: Over/unders (point totals)
- New England Patriots at Seattle Seahawks: 44.5
- San Francisco 49ers vs Los Angeles Rams: 48.5
- Chicago Bears at Carolina Panthers: 47.5
- Tampa Bay Buccaneers at Cincinnati Bengals: 50.5
- New Orleans Saints at Detroit Lions: 50.5
- Buffalo Bills vs Houston Texans: 44.5
- Baltimore Ravens vs Indianapolis Colts: 47.5
- Cleveland Browns vs Jacksonville Jaguars: 40.5
- Atlanta Falcons vs Pittsburgh Steelers: 42.5
- New York Jets vs Tennessee Titans: 39.5
- Arizona Cardinals at Los Angeles Chargers: 47.5
- Miami Dolphins at Las Vegas Raiders: 40.5
- Green Bay Packers vs Minnesota Vikings: 45.5
- Washington Commanders vs Philadelphia Eagles: 45.5
- Dallas Cowboys at New York Giants: 48.5
- Denver Broncos at Kansas City Chiefs: 43.5
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: NFL Week 1 odds, point spreads, moneylines, over/unders for games
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