The Ohio State Buckeyes and Iowa Hawkeyes play on Saturday, Oct. 3, 2026, at Kinnick Stadium in Iowa City, Iowa, in a game on thecollege football Week 5 schedule.
Which team will win the college football Week 5 game?
Check out these college football Week 5 picks and college football Week 5 predictions for the game, which can be seen at 12:30 p.m. MST on CBS (stream with FUBO).
Ohio State is a 12.5-point favorite over Iowa in college football Week 5 odds for the game, according to BetMGM Sportsbook.
The Buckeyes are -550 on the moneyline, while the Hawkeyes are +425. The over/under (point total) for the game is set at 45.5 points.
Watch Ohio State vs Iowa on FUBO (free trial)
Sporting News: Ohio State 34, Iowa 19
Bill Bender writes: "Iowa will be a trendy underdog pick here. The Buckeyes,
however, present a different challenge in the passing game with Jeremiah Smith, who has 617 receiving yards and seven TDs. The Buckeyes have allowed 171.5 rushing yards per game to Power 4 opponents, which could allow the Hawkeyes to hang around at home. The Hawkeyes are 5-1-1 ATS as an underdog since 2024."
Bookies.com: Bet Iowa with the points vs Ohio State
Bill Speros writes: "Iowa City takes the stage as the center of the College Football Metaverse with this top-15 matchup. Kirk Ferentz and the Hawkeyes rallied for a rock-fight 20-19 upset of Michigan on the last play of the game. And this time, Michigan's Time Travel Machine failed to engage. Ohio State QB Julian Sayin, WR Jeremiah Smith and RB Bo Jackson enter this game as the best 1-2-3 punch in college football. Ferentz and Iowa thrive on defense. Our model has the Buckeyes winning by 10 against a line of 14. Combined, these teams are 6-1 ATS. Something breaks here. The Buckeyes have scored 102 points since losing to Texas. Kinnick at 3:30 on CBS tempers that number."
Dimers.com: Ohio State 30, Iowa 17
It writes: "After extensive simulations, our model gives Ohio State a win probability of 84%, while Iowa has a win probability of 16%."
ESPN: Ohio State has an 82.9% chance to defeat Iowa
The site gives the Hawkeyes a 17.1% shot at winning the college football Week 5 game.
Sports Betting Dime: Ohio State 23.6, Iowa 22.6
The site's formula predicts that the Buckeyes will beat the Hawkeyes in the Week 5 college football game.
Picks and Parlays: Bet Iowa with the points vs Ohio State
Kim Smith writes: "Ohio State is capable of winning this game without covering. Iowa’s defense has been too effective to ignore, allowing just 8.0 points per game while the Hawkeyes enter undefeated and fresh off a road win against Michigan. Ohio State represents Iowa’s toughest offensive challenge by a considerable margin, but asking the Buckeyes to win by two touchdowns at Kinnick is substantial. Iowa’s defense should keep the Hawkeyes within the number."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Ohio State vs Iowa picks, predictions for college football Week 5 game
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