The LSU Tigers and Ole Miss Rebels play on Saturday, Sept. 19, 2026, at Vaught-Hemingway Stadium in Oxford, Mississippi, in a game on the college football Week 3 schedule.
Which team will win the college football Week 3 game?
Check out these college football Week 3 picks and college football Week 3 predictions for the game, which can be seen at 4:30 p.m. MST on ABC (stream with FUBO).
LSU is a 3-point favorite over Ole Miss in college football Week 3 odds for the game, according to BetMGM Sportsbook.
The Tigers are -150 on the moneyline, while the Rebels are +125. The over/under (point total) for the game is set at 59.5 points.
College football Week 3 picks: Georgia vs Arkansas | North Carolina vs Clemson | Kentucky vs Texas A&M | Florida State vs Alabama
| SMU vs Louisville | Mississippi State vs South Carolina | Florida vs Auburn | Michigan State vs Notre Dame | LSU vs Ole Miss
Watch Mississippi State vs LSU on FUBO (free trial)
Sportsnaut: LSU 21, Ole Miss 14
Matt Johnson writes: "So much of the focus for the LSU Tigers vs Ole Miss Rebels matchup will rightfully be on Lane Kiffin’s return to Vaught-Hemingway-Stadium. After all, that’s the reason why ESPN College GameDay is in Oxford for Week 3. LSU quarterback Sam Leavitt and running back Dilin Jones will certainly be fired up to deliver an offensive clinic for their head coach in front of what might be the most hostile crowd we’ll see in college football all year. With that said, we think this game is decided by something else."
Bookies.com: Bet LSU on the moneyline vs Ole Miss
Bill Speros writes: "Old Testament meets New Testament. The Prodigal Son returns to Oxford to face the Biblical wrath those whom he scorned. Once the hype and hate abates, and the riots quell, LSU asserts its dominance on both sides of the ball. The Tigers were caught looking ahead to this game during the first half of their win over La Tech Saturday. The Tigers eventually silence the mob, and Ole Miss in the process."
Big 12 football Week 3 picks: Houston vs Texas Tech | Tulane vs Kansas State | Bowling Green vs Iowa State | Arizona State vs Kansas | Utah State vs Utah | BYU vs Colorado State | West Virginia vs Virginia | Colorado vs Northwestern | Northern Illinois vs Arizona | The Republic's predictions
Dimers.com: LSU 30, Ole Miss 28
It writes: "After extensive simulations, our model gives LSU a win probability of 57%, while Mississippi has a win probability of 43%."
ESPN: LSU has a 65% chance to defeat Ole Miss on Saturday
The site gives the Rebels a 35% shot at winning the college football Week 3 game.
Sports Betting Dime: Ole Miss 26.7, LSU 20.3
The site's formula predicts that the Rebels will beat the Tigers in the Week 3 college football game.
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: LSU vs Ole Miss picks, predictions, odds for Week 3 game Saturday
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