The Washington Commanders and San Francisco 49ers play on Monday, Oct. 19, at the 49ers' Levi's Stadium in a game on the NFL Week 6 schedule.
Which team will win the NFL Week 6 Monday Night Football game?
Check out these NFL Week 6 picks and NFL Week 6 predictions for the game, which can be seen at 5:15 p.m. MST on ESPN and ABC. (stream with FUBO).
The 49ers are a 7.5-point favorite over the Commanders in NFL Week 6 odds for the game, courtesy of BetMGM Sportsbook.
San Francisco is -400 on the moneyline, while Washington is +310. The over/under (point total) is set at 51 points.
NFL Week 6 picks: Seahawks vs Broncos | Texans vs Jaguars | Bears vs Falcons | Ravens vs Browns | Titans vs Colts | Jets vs Patriots | Saints vs Giants | Panthers vs Eagles
| Steelers vs Buccaneers | Cardinals vs Rams | Chargers vs Chiefs | Bills vs Raiders | Cowboys vs Packers | Commanders vs 49ers | The Republic's predictions
Watch Commanders vs 49ers on FUBO (free trial)
The Arizona Republic: 49ers 27, Commanders 24
Jeremy Cluff writes: "The Commanders desperately need to win this game after blundering their tie against the Giants in Week 5. Easier said than done against a 49ers team that looks like it is the NFL's best so far this season. Brock Purdy will be efficient, and San Francisco hands Jayden Daniels and the Commanders a very tough loss."
Bookies.com: Bet the under in 49ers vs Commanders game
Bill Speros writes: "Jayden Daniels and the Commanders botched their chance for a potential game-winning field goal Sunday against the Giants and settled for a 27-27 tie. San Francisco survived a 32-29 heavyweight bout at Seattle in a game that featured seven turnovers. Injuries have returned to decimate the 49ers this season. But Brock Purdy still has a banged-up Mike Evans, George Kittle and CMC at his disposal. This game carries a 50-plus-point total, given that these teams combined for 59 points in Week 5. But the Commanders have yet to prove they can deliver on the road. Avoid the hook at 7.5 here and go with the under."
Sports Betting Dime: 49ers 36, Commanders 13.6
The site's formula predicts that the 49ers will win the NFL Week 6 game against the Commanders.
VOTE: Who will win the Commanders vs 49ers game in NFL Week 6? (The Arizona Republic's prediction: https://t.co/OpAZpHTC5I) #NFL #RaiseHail #FTTB
— Jeremy Cluff (@Jeremy_Cluff) October 12, 2026
ESPN: 49ers have an 86.2% chance to beat Commanders
The site gives the Commanders a 13.7% shot at winning the NFL Week 6 game, with the remaining percentage accounting for a tie.
Dimers: 49ers 29, Commanders 21
It writes: "The numbers give the Commanders a win probability of 24.2%, while the 49ers have a win probability of 75.8%."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Commanders vs 49ers picks, predictions, odds for NFL Week 6 game
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