The Detroit Lions and Buffalo Bills play on Thursday, Sept. 17, at the Bills' Highmark Stadium in a game on the NFL Week 2 schedule.
Which team will win the NFL Week 2 Thursday Night Football game?
Check out these NFL Week 2 picks and NFL Week 2 predictions for the game, which can be seen at 5:15 p.m. MST on Amazon Prime (stream with Prime Video).
The Bills are a 4.5-point favorite over the Lions in NFL Week 2 odds for the game, courtesy of BetMGM Sportsbook.
Buffalo is -210 on the moneyline, while Detroit is +175. The over/under (point total) is set at 53.5 points.
Watch Lions vs Bills on Amazon Prime Video
The Arizona Republic: Bills 30, Lions 24
Jeremy Cluff writes: "The Bills are playing their first NFL regular season game in the new Highmark Stadium. Expect a lot of fireworks. And expect
Josh Allen to be Josh Allen for Buffalo."
Bookies.com: Bet the Bills to cover vs Lions
Bill Speros writes: "Will the Bills shine in the prime-time debut of their new stadium? Both teams come off hard-fought wins on Sunday. The Lions blew a 21-point lead but held on to stop a 2-point conversion in overtime to snag the win. The Bills tore up Houston’s so-called 'best defense in the league.' No 36-point effort on a short week here. But we’ll get the Bills to win and cover. Make sure you stick to the 3 here."
Sports Betting Dime: Bills 29.2, Lions 24.4
The site's formula predicts that the Bills will win the NFL Week 2 game against the Lions.
ESPN: Bills have a 66.9% chance to beat Lions
The site gives the Lions a 32.9% shot at winning the NFL Week 2 game, with the remaining percentage accounting for a tie.
Dimers: Bills 28, Lions 24
It writes: "The numbers give the Lions a win probability of 36.8%, while the Bills have a win probability of 63.2%."
BetMGM: Bet the Bills to score over 29.5 points vs Lions
Nick Hennion writes: "Based on the situational spot for the Lions defense and Buffalo’s prior success against this unit, my Bills vs Lions prediction is the Bills Over 29.5 Points. It’s a high number to clear on short rest, but that’s how little faith I have in this Detroit defense. In the first half, the Lions caused havoc on the Saints as a seven-point home favorite. But the unit crumbled in the second half. Kelvin Sheppard’s defense allowed 24 points before overtime."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Lions vs Bills picks, predictions, odds for NFL Week 2 game Thursday
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