Who will win the Indianapolis Colts vs Houston Texans NFL Week 3 game?
The Houston Texans and Indianapolis Colts play on Sept. 27, at the Colts' Lucas Oil Stadium in a game on the NFL Week 3 schedule.
What do NFL Week 3 odds say about the Sunday game? Who are NFL Week 3 predictions and NFL Week 3 picks taking in the game?
Which team has the best chance to win the game according to NFL Week 3 win probabilities
?Check out The Arizona Republic's score prediction for the Sunday football game, as well as Texans vs Colts picks, odds and win chances for the Week 3 NFL game, which can be seen at 10 a.m. MST on CBS (stream with FUBO).
NFL Week 3 predictions: Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs
at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | Win probabilities
Watch Texans at Colts on FUBO (free trial)
Indianapolis Colts vs Houston Texans prediction
The Arizona Republic is predicting a 23-20 win for the Texans over the Colts in the NFL Week 3 Sunday football game.
Jeremy Cluff writes: "The Texans made the playoffs in 2025 after starting the season 0-3. They don't want to try to have to repeat that feat in 2026. Some big defensive plays and key David Montgomery runs will help them avoid it."
Houston Texans vs Indianapolis Colts picks
Will the Colts or Texans win the game in NFL Week 3?
Bookies.com says to bet the over in the Colts vs Texans game.
Sports Betting Dime's formula predicts a 40.5-29.3 win for the Texans over the Colts.
Dimers.com's final score prediction? Texans 23, Colts 22.
Sportnaut is predicting a 21-14 win for the Texans over the Colts.
NFL Week 3 picks: Falcons at Packers | Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | The Republic's predictions
Indianapolis Colts vs Houston Texans win probabilities
The Texans have a 52.5% chance to beat the Colts, according to ESPN.
The site gives the Colts a 47.1% shot at winning the NFL Week 3 game, with the remaining percentage accounting for a tie.
Houston Texans vs Indianapolis Colts odds
The Texans are a 2.5-point favorite over the Colts in NFL Week 3 odds for the game, courtesy of BetMGM Sportsbook.
Houston is -140 on the moneyline, while Indianapolis is +115.
The over/under (point total) is set at 43.5 points.
NFL Week 3 odds: Falcons at Packers | Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | Point spreads, moneylines, totals for betting
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Colts vs Texans predictions, picks, odds for NFL Week 3 game Sunday
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