Who will win the Los Angeles Chargers vs Arizona Cardinals NFL Week 1 game today?
The Arizona Cardinals and Los Angeles Chargers play on Sept. 13, at the Chargers' SoFi Stadium in a game on the NFL Week 1 schedule.
What do NFL Week 1 odds say about the Sunday game? Who are NFL Week 1 predictions and NFL Week 1 picks taking in the game?
Which team has the best chance to win the game according to NFL Week 1 win probabilities
?Check out The Arizona Republic's score prediction for the Sunday football game, as well as Cardinals vs Chargers picks, odds and win chances for the NFL Week 1 game, which can be seen at 1:25 p.m. MST on CBS (stream with FUBO).
NFL Week 1 picks: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals
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Los Angeles Chargers vs Arizona Cardinals prediction
The Arizona Republic is predicting a 30-21 win for the Chargers over the Cardinals in the NFL Week 1 Sunday football game.
Jeremy Cluff writes: "The Mike LaFleur era begins with a tough test against the Chargers. Arizona is the biggest underdog of the week. Can the Cardinals just keep it close?"
Arizona Cardinals vs Los Angeles Chargers picks
Will the Chargers or Cardinals win the game in NFL Week 1?
Bookies.com says to bet the under in Chargers vs Cardinals game.
Sports Betting Dime's formula predicts a 26.4-13.1 win for the Chargers over the Cardinals.
Dimers.com's final score prediction? Chargers 27, Cardinals 17.
BetMGM is taking the Cardinals with the points against the Chargers.
Los Angeles Chargers vs Arizona Cardinals win probabilities
The Chargers have an 80.8% chance to beat the Cardinals on Sunday, according to ESPN.
The site gives the Cardinals a 19.1% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Arizona Cardinals vs Los Angeles Chargers odds
The Chargers are a 10.5-point favorite over the Cardinals in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.
Los Angeles is -550 on the moneyline, while Arizona is +425.
The over/under (point total) is set at 47.5 points.
NFL Week 1 odds: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | Point spreads, moneylines, over/unders
NFL's highest paid players in 2026: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Chargers vs Cardinals predictions, picks, odds for NFL Week 1 game
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