The Oregon Ducks and Oklahoma State Cowboys play on Saturday, Sept. 12, 2026, at Boone Pickens Stadium in Stillwater, Oklahoma, in a game on the college football Week 2 schedule.
Which team will win the
college football Week 2 game?
Check out these college football Week 2 picks and college football Week 2 predictions for the game, which can be seen at 9 a.m. MST on ESPN (stream with FUBO).
Oregon is a 22.5-point favorite over Oklahoma State in college football Week 2 odds for the game, according to BetMGM Sportsbook.
The Ducks are -2000 on the moneyline, while the Cowboys are +1200. The over/under (point total) for the game is set at 57.5 points.
Watch Oregon vs Oklahoma State on FUBO (free trial)
The Arizona Republic: Oregon 38, Oklahoma State 17
Jeremy Cluff writes: "Oregon got a wake-up call against Boise State. Bad news for the Cowboys, who are a 22.5-point underdog at home. Dante Moore and company will cruise in Stillwater, Oklahoma."
Bookies.com: Bet the under in Oklahoma State vs Oregon game
Bill Speros writes: "The Ducks were pushed hard by Boise State in their opener in Eugene. Now, they head to Stillwater for what will be an 11 a.m. local time kick. The Cowboys remain in free-fall. They’ve now lost 12 straight, including Eric Morris's debut last week in a 24-10 loss to G5 Tulsa. Dante Moore continues his Heisman push with another 375+ yard passing game. The difference this week is that OSU won’t test Oregon’s defense in the same way Boise State did. The Ducks need a runaway after their Week 1 scare. They get it here. Thanks to the defense."
Dimers.com: Oregon 39, Oklahoma State 17
It writes: "After extensive simulations, our model gives Oregon a win probability of 91%, while Oklahoma State has a win probability of 9%."
ESPN: Oregon has a 93% chance to defeat Oklahoma State on Saturday
The site gives the Cowboys a 7% shot at winning the college football Week 2 game.
Sports Betting Dime: Oregon 34, Oklahoma State 14.2
The site's formula predicts that the Ducks will beat the Cowboys in the Week 2 college football game.
Ducks Wire: Oregon a big favorite vs Oklahoma State
Logan Brown writes: "FanDuel Sportsbook has opened the betting lines with Oregon as a 21.5-point favorite. The Ducks have -2100 odds on the money line, which are favorable, but considerably less than last week. Oklahoma State can be bought at +1060 odds. Once again, the oddsmakers are expecting the Ducks to put up points, setting the over/under at 57.5 points. Considering the Cowboys only scored 10 points last week against Tulsa, many of those points are expected to come from Oregon's offense."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Oregon vs Oklahoma State picks, predictions, odds for Week 2 game
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