The Louisiana Ragin' Cajuns and USC Trojans play on Saturday, Sept. 12, 2026, at Los Angeles Memorial Coliseum in Los Angeles, in a game on the college football Week 2 schedule.
Which team will win the college football Week 2 game?
Check out these college football Week 2 picks and college football Week 2 predictions for the game, which can be seen at 8 p.m. MST on Big Network (stream with FUBO).
USC is a 30.5-point favorite over Louisiana in college football Week 2 odds for the game, according to BetMGM Sportsbook.
The Trojans are -10000 on the moneyline, while the Ragin' Cajuns are +2500. The over/under (point total) for the game is set at 60.5 points.
Watch Louisiana vs USC on FUBO (free trial)
Sports Illustrated: USC 52, Louisiana 13
Caden Handwork writes: "For the first time, the Trojans
will face the Louisiana Ragin' Cajuns on Sept. 12 at the Coliseum. This is another game that the Trojans should be able to win comfortably. Louisiana is coming off a 2025 season finishing at 6-7 overall and went 5-3 in Sun Belt play."
Bookies.com: Bet the under in Louisiana vs USC game
Bill Speros writes: "The Trojans play their third home game of the season and have another cupcake on the menu in Louisiana. USC won 49-26 Saturday, but its second-stringers allowed San Jose State to score an easy cover on the 38.5-point spread. Expect a similar story here. Clearly, oddsmakers factored in a similar scenario given the 28.5—point spread and 63.5-point total. USC’s won 10 straight at the Coliseum and gets a Sun Belt foe playing a late-night game on the West Coast. Jayden Maiava is ready for the Big Ten. He’ll sit in the second half here. This time, USC’s backups deliver on the under."
Dimers.com: USC 44, Louisiana 13
It writes: "After extensive simulations, our model gives Louisiana-Lafayette a win probability of 3%, while Southern California has a win probability of 97%."
ESPN: USC has a 96.9% chance to defeat Louisiana on Saturday
The site gives the Ragin' Cajuns a 3.1% shot at winning the college football Week 2 game.
Sports Betting Dime: Louisiana 24.3, USC 20.8
The site's formula predicts that the Ragin' Cajuns will upset the Trojans in the Week 2 college football game.
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: USC vs Louisiana picks, predictions, odds for Week 2 game Saturday
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