Monday Night Football predictions, picks, odds for Rams vs Giants game

Who will win on Monday Night Football in NFL Week 2? The New York Giants and Los Angeles Rams play on Monday, Sept. 21, at the Rams' SoFi Stadium in the final game on the NFL Week 2 schedule. What do NFL Week 2 odds say about the Monday Night Football game? Who are NFL Week 2 predictions and NFL Wee

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Who will win on Monday Night Football in NFL Week 2?

The New York Giants and Los Angeles Rams play on Monday, Sept. 21, at the Rams' SoFi Stadium in the final game on the NFL Week 2 schedule.

What do NFL Week 2 odds say about the Monday Night Football game? Who are NFL Week 2 predictions and NFL Week 2 picks taking in the game?

Which team has the best chance to win the game according to NFL Week 2 win probabilities?

Check out The Arizona Republic's score prediction for the Monday Night Football game, as well as Giants vs Rams picks, odds and win chances for the NFL Week 2 game, which can be seen at 5:15 p.m.. MST on ESPN and ABC (stream with FUBO).

Watch Monday Night football games on FUBO (free trial)

Monday Night Football prediction for Rams vs Giants game

The Arizona Republic is predicting a 33-23 win

for the Rams over the Giants in the NFL Week 2 Monday Night Football game.

Jeremy Cluff writes: "The Rams were humbled in a Week 1 loss to the 49ers. Bad news for the Giants. Puka Nacua and Los Angeles take out their frustrations on New York."

Monday Night Football picks for Giants vs Rams game

Will the Rams or Giants win the Monday Night Football game in NFL Week 2?

Bookies.com says to bet the Rams to cover against the Giants.

Sports Betting Dime's formula predicts a 34.7-17.9 win for the Rams over the Giants.

Dimers.com's final score prediction? Rams 28, Giants 20.

Sportnaut is predicting a 24-21 win for the Giants over the Rams.

Monday Night Football win probabilities for Rams vs Giants game

The Rams have a 66.3% chance to beat the Giants, according to ESPN.

The site gives the Giants a 33.5% shot at winning the NFL Week 2 game, with the remaining percentage accounting for a tie.

Monday Night Football odds for Giants vs Rams game

The Rams are a 7-point favorite over the Giants in NFL Week 2 odds for the game, courtesy of BetMGM Sportsbook.

Los Angeles is -350 on the moneyline, while New York is +275.

The over/under (point total) is set at 48.5 points.

New York Giants wide receiver Malik Nabers (1) and New York Giants quarterback Jaxson Dart (6) stand together as fireworks go off starting the beginning of a week one opening game between the New York Giants and Dallas Cowboys at Metlife Stadium on Sunday, Sept. 13, 2026, in East Rutherford, New Jersey.

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Monday Night Football predictions, picks, odds for Rams vs Giants game

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