The Las Vegas Raiders and Los Angeles Chargers play on Sunday, Sept. 20, at the Chargers' SoFi Stadium in a game on the NFL Week 2 schedule.
Which team will win the NFL Week 2 game?
Check out these NFL Week 2 picks and NFL Week 2 predictions for the game, which can be seen at 1:05 p.m. MST on CBS (stream with FUBO).
The Chargers are a 6.5-point favorite over the Raiders in NFL Week 2 odds
for the game, courtesy of BetMGM Sportsbook.Los Angeles is -325 on the moneyline, while Las Vegas is +260. The over/under (point total) is set at 43.5 points.
Watch Raiders vs Chargers on FUBO (free trial)
The Arizona Republic: Chargers 23, Raiders 20
Jeremy Cluff writes: "The Chargers won't drop a second straight game as a big favorite to open the season, right? Justin Herbert and company bound back here."
Bookies.com: Bet the Raiders with the points vs Chargers
Bill Speros writes: "Usually, the Chargers wait until January to collapse. They beat the rush this year. The Bolts short-circuited millions of survivor pools in Week 1 thanks to an embarrassing 26-14 home loss to the Cardinals in Mike LaFleur’s head coaching debut. According to Circa’s Mike Palm, $10.3 million was lost by people who picked the Chargers in that book’s Survivor and Grandisimo contests. The Raiders got their win out of the way early in a scrimmage against Miami. The Bolts bounce back this week. Maybe . . . But not at this number."
Sports Betting Dime: Chargers 22.3, Raiders 6.2
The site's formula predicts that the Chargers will win the NFL Week 2 game against the Raiders.
ESPN: Chargers have a 68.7% chance to beat Raiders
The site gives the Raiders a 31.1% shot at winning the NFL Week 2 game, with the remaining percentage accounting for a tie.
Dimers: Chargers 25, Raiders 18
It writes: "The numbers give the Raiders a win probability of 27.7%, while the Chargers have a win probability of 72.3%."
Sportsnaut: Chargers 28, Raiders 24
Matt Johnson writes: "This is another Week 2 matchup where there would seemingly be a clear favorite (Los Angeles Chargers) that could realistically lose to a ‘lesser’ team (Las Vegas Raiders) and fall to an unexpected zero-to-two start in 2026. Week 1 showcased how serious the issues are right now on the Chargers’ offensive line, and that becomes an even greater issue when it is evident the defense will not be as good with Jesse Minter gone. So, there is an opportunity here for the Raiders. SoFi Stadium will be filled out by Raider Nation, and if Las Vegas can find ways to get Maxx Crosby to attack inside with stunts, Las Vegas could pull out a two-to-zero record that no one saw coming. However, the talent disparity at quarterback between Justin Herbert versus Fernando Mendoza leads us to believe the Chargers avoid a major setback to their playoff hopes and win this one in the fourth quarter."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Raiders vs Chargers picks, predictions, odds for NFL Week 2 game
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