The Arizona Cardinals and San Francisco 49ers play on Sunday, Sept. 27, at the 49ers' Levi's Stadium in a game on the NFL Week 3 schedule.
Which team will win the NFL Week 3 game?
Check out these NFL Week 3 picks and NFL Week 3 predictions for the game, which can be seem at 1:05 p.m. MST on FOX (stream with FUBO).
The 49ers are an 8.5-point favorite over the Cardinals in NFL Week 3 odds
for the game, courtesy of BetMGM Sportsbook.San Francisco is -450 on the moneyline, while Arizona is +340. The over/under (point total) is set at 48 points.
Watch Cardinals vs 49ers on FUBO (free trial)
The Arizona Republic: 49ers 31, Cardinals 17
Jeremy Cluff writes: "The Cardinals fell back to Earth in their Week 2 loss to the Seahawks. We have a feeling more humble pie is coming. Brock Purdy and San Francisco
have looked really good through two weeks."
Bookies.com: Bet the 49ers to cover vs Cardinals
Bill Speros writes: "More NFC West-on-NFC West crime. The 49ers have become an after-thought in the NFC West, thanks to the Hollywood Rams and Super Bowl champion Seahawks. But the 49ers may have the deepest overall roster in the NFL. They’ve outscored their opponents 62-20. The Cardinals reverted to form in Week 2 in a 31-7 loss to the Seahawks. Keep that difference in mind here, where point differential and strength of victory are both divisional tie-breakers."
Sports Betting Dime: 49ers 17.2, Cardinals 13
The site's formula predicts that the 49ers will win the NFL Week 3 game against the Cardinals.
ESPN: 49ers have a 90.3% chance to beat Cardinals
The site gives the Cardinals a 9.6% shot at winning the NFL Week 3 game, with the remaining percentage accounting for a tie.
Dimers: 49ers 28, Cardinals 19
It writes: "The numbers give the Cardinals a win probability of 22.4%, while the 49ers have a win probability of 77.6%."
Sportsnaut: 49ers 35, Cardinals 24
Matt Johnson writes: "The Arizona Cardinals should continue to exceed expectations this season, but the gap in talent, roster depth and coaching between these two teams is massive. Brock Purdy looks excellent this year, and with George Kittle another week removed from his return from Achilles surgery, the San Francisco 49ers‘ passing game should keep getting better. Defensively, Nick Bosa and Fred Warner can do enough to limit Jacoby Brissett from airing it out deep, all the while containing Trey McBride."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Cardinals vs 49ers picks, predictions, odds for NFL Week 3 game Sunday
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