The Houston Texans and Jacksonville Jaguars play on Sunday, Oct. 18, at Wembley Stadium in London, England, in a game on the NFL Week 6 schedule.
Which team will win the NFL Week 6 international football game?
Check out these NFL Week 6 picks and NFL Week 6 predictions for the game, which can be seen at 6:30 a.m. MST on NFL Network (stream with FUBO).
The Jaguars are a 2.5-point favorite over the Texans in NFL Week 6 odds for the game, courtesy of BetMGM Sportsbook.
Jacksonville is -145 on the moneyline, while Houston is +125. The over/under (point total) is set at 43 points.
Watch Texans vs Jaguars on FUBO (free trial)
The Arizona Republic: Texans 23, Jaguars 20
Jeremy Cluff writes: "This game could be a must-win for the Texans, who sit at 1-4, well behind the 4-1 Jaguars in the AFC South
standings. C.J. Stroud will make some big plays, but Houston's defense will be the reason the Texans get the upset win in London."
Bookies.com: Bet the Jaguars to cover vs Texans
Bill Speros writes: "The NFL plays in London for the third consecutive week. The Jaguars, who pulled off a thrilling 19-17 win over the Eagles in London thanks to a last-second 57-yard field goal, stick around the U.K. for another week to face the Houston Texans. Oddsmakers caught up with the Jaguars in Week 5, as they failed to cover as 7.5-point favorites against an injury-decimated Eagles roster. This game opened with Jacksonville as a 3-point underdog last spring. That number has since pulled a 180. Houston got off the schneid Sunday with its first win of 2026. C.J. Stroud and the Texans — even with Marvin Harrison Jr. — don't carry enough octane to keep up with Jacksonville. The Jaguars are for real this season. They prove it again this week with the cover."
Sports Betting Dime: Jaguars 27.7, Texans 12.3
The site's formula predicts that the Jaguars will win the NFL Week 6 game against the Texans.
ESPN: Jaguars have a 58.8% chance to beat Texans
The site gives the Texans a 40.9% shot at winning the NFL Week 6 game, with the remaining percentage accounting for a tie.
Dimers: Jaguars 24, Texans 21
It writes: "The numbers give the Texans a win probability of 37.1%, while the Jaguars have a win probability of 62.9%."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don't miss a thing.
This article originally appeared on Arizona Republic: Texans vs Jaguars picks, predictions, odds for NFL Week 6 game
Our editors independently choose our recommendations. Some content is produced with paid support from a third party, however our editorial decisions remain independent. If you buy through our links, the USA TODAY Network may earn a commission. Prices and availability may change.
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
