The Washington Huskies and USC Trojans play on Saturday, Oct. 3, at Los Angeles Memorial Coliseum in Los Angeles in a game on the college football Week 5 schedule.
Which team will win the college football Week 5 game?
Check out these college football Week 5 picks and college football Week 5 predictions for the game, which can be seen at 4:30 p.m. MST on NBC (stream with FUBO).
USC is a 9.5-point favorite over Washington in college football Week 5 odds for the game, according to BetMGM Sportsbook.
The Trojans are -375 on the moneyline, while the Huskies are +300. The over/under (point total) for the game is set at 57.5 points.
Watch Washington vs USC on FUBO (free trial)
Sporting News: USC 34, Washington 23
Bill Bender writes: "How will USC bounce back after a 41-27 loss to Oregon? The
Huskies average just 3.8 yards per carry — and quarterback Demond Williams Jr. is the team's leading rusher. Washington won the last meeting 26-21 in 2024 — so the pressure is on Jayden Maiava in a battle of one-loss Big Ten teams."
Bookies.com: Bet the over in USC vs Washington game
Bill Speros writes: "The Trojans received a well-deserved 41-27 comeuppance at the hands of Oregon on Saturday night after USC's Desman Stephens II laughed off his assault on Dante Moore. Stephens and head coach Lincoln Riley issued apologies Sunday, and Stephens is out this week. This is USC's fourth home game of the season against just one road trip, to Rutgers. USC QB Jayden Maiava's best should be on display against the Dubs and the Huskies. These teams are a combined 1-6 ATS. Our model has USC winning by 8.1 points against a line of 9.5. Washington's defense can contain USC, but not for 60 minutes — and the Huskies won't be able to keep pace late as the points amass."
Dimers.com: USC 33, Washington 25
It writes: "After extensive simulations, our model gives Washington a win probability of 24%, while Southern California has a win probability of 76%."
ESPN: USC has an 83.8% chance to defeat Washington
The site gives the Huskies a 16.2% shot at winning the college football Week 5 game.
Sports Betting Dime: USC 26.2, Washington 24.9
The site's formula predicts that the Trojans will beat the Huskies in the Week 5 college football game.
Picks and Parlays: Bet USC to beat Washington
Kim Smith writes: "This is the Huskies’ first road trip of the season, and the Coliseum represents a substantial increase in difficulty. USC’s offensive ceiling and home field make the Trojans the side."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Washington vs USC picks, predictions for college football Week 5 game
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