The Alabama Crimson Tide and Mississippi State Bulldogs play on Saturday, Oct. 3, 2026, at Davis Wade Stadium in Starkville, Mississippi, in a game on the college football Week 5 schedule.
Which team will win the college football Week 5 game?
Check out these college football Week 5 picks and college football Week 5 predictions for the game, which can be seen at 9 a.m. MST on ABC (stream with FUBO).
Alabama is a 6-point favorite over Mississippi State in college football Week 5 odds for the game, according to BetMGM Sportsbook.
The Crimson Tide are -225 on the moneyline, while the Bulldogs are +185. The over/under (point total) for the game is set at 60.5 points.
Watch Alabama vs Mississippi State on FUBO (free trial)
Sporting News: Alabama 31, Mississippi State 28
Bill Bender writes: "This is the
best game of the week – a quarterback duel between Russell and Taylor that has Heisman Trophy implications. Taylor has 14 TD passes and just two interceptions, and he will test the Crimson Tide secondary in the vertical passing game. Russell is working on back-to-back 300-yard games. Alabama is 6-3 S/U in SEC road games under Kalen DeBoer, including a 4-1 S/U record against ranked opponents. Mississippi State's last win against Alabama was a 17-12 victory in Nick Saban's first season on Nov. 10, 2007."
Bookies.com: Bet Alabama to cover vs Mississippi State
Bill Speros writes: "The Tide may have ended Shane Beamer's run as South Carolina coach with a dominant 49-18 win and cover over the Gamecocks. Alabama rides a 16-game winning streak in this series, and an 11 a.m. local kickoff at Davis Wade Stadium tempers some of MSU's home-field advantage. Keelon Russell and the Tide's offense keep pace with Texas and Georgia in the SEC title race. Our model has the Tide winning and snagging the cover."
Dimers.com: Alabama 33, Mississippi State 27
It writes: "After extensive simulations, our model gives Alabama a win probability of 67%, while Mississippi State has a win probability of 33%."
ESPN: Alabama has a 74.2% chance to defeat Mississippi State
The site gives the Bulldogs a 25.9% shot at winning the college football Week 5 game.
Sports Betting Dime: Alabama 32.1, Mississippi State 31.8
The site's formula predicts that the Tar Heels will beat the Bulldogs in the Week 5 college football game.
Picks and Parlays: Bet Mississippi State with the points vs Alabama
Kim Smith writes: "Mississippi State gets the side selection at +4. Alabama remains the favorite for a reason, but the value has shifted toward the Bulldogs as the spread has moved away from the key number of three. Mississippi State gets home-field advantage and has played well enough early this season to warrant considerably more respect than this matchup might have commanded before the year began. The additional point created by the early movement matters. Alabama could absolutely escape Starkville with a victory while Mississippi State still covers the spread. At +4, the Bulldogs have protection against several realistic one-score outcomes. If Mississippi State moves to +4.5 or better, the value improves further. At +3, this becomes considerably less attractive."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Alabama vs Mississippi State picks, predictions, odds for Week 5 game
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