The Mississippi State Bulldogs and South Carolina Gamecocks play on Saturday, Sept. 19, 2026, at Williams-Brice Stadium in Columbia, South Carolina, in a game on the college football Week 3 schedule.
Which team will win the college football Week 3 game?
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and college football Week 3 predictions for the game, which can be seen at 1:15 p.m. MST on SEC Network (stream with FUBO).South Carolina is a 4-point favorite over Mississippi State in college football Week 3 odds for the game, according to BetMGM Sportsbook.
The Gamecocks are -185 on the moneyline, while the Bulldogs are +150. The over/under (point total) for the game is set at 59.5 points.
Watch South Carolina vs Mississippi State on FUBO (free trial)
Sportsnaut: Mississippi State 31, South Carolina 28
Matt Johnson writes: "The Week 3 matchup between the Mississippi State Bulldogs and South Carolina Gamecocks is a litmus test for both programs, with the victor all but guaranteed to crack the top 25 rankings on Sunday morning. Gamecocks quarterback LaNorris Sellers is obviously the bigger name but Mississippi State’s emerging star Kamario Taylor is having the better season thus far. Taylor is coming off consecutive starts with at least 200 passing yards, 59-plus rushing yards and three-plus touchdowns with the help of senior wideout Anthony Evans III. We’re fascinated to see how the young signal-caller handles South Carolina’s pass rush, but the Bulldogs might have the advantage on the perimeter over the Gamecocks’ cornerbacks. Home-field advantage and experience do matter here for South Carolina, but Mississippi State’s win last Saturday in Minnesota and what Jeff Lebby is doing with this offense push us to picking the Bulldogs to come out on top."
Stat Salt: Bet Mississippi State with the points vs South Carolina
Kim Smith writes: "South Carolina deserves respect after allowing only nine points through two games, but Mississippi State's 38-13 road victory over Minnesota is the most meaningful result either team has produced. The Bulldogs have scored 100 points through two games and have already demonstrated that they can travel successfully. Getting through the key number of three makes Mississippi State the value side in what should be a competitive SEC opener."
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Dimers.com: South Carolina 32, Mississippi State 27
It writes: "After extensive simulations, our model gives Mississippi State a win probability of 35%, while South Carolina has a win probability of 65%."
ESPN: South Carolina has a 64.5% chance to defeat Mississippi State
The site gives the Bulldogs a 35.5% shot at winning the college football Week 3 game.
Doc's Sports: Take South Carolina to cover vs Mississippi State
Josh Schonwald writes: "South Carolina has given up a total of 121 rushing yards (60.5 yards/game) as well as 0 touchdown via the rush for the campaign. They have conceded 1 touchdown via the pass and 130.5 yards/outing, which puts them in 18th in D-1. They have compiled no fumbles and 1 interception this year. The Gamecocks defense has been on the field for 111 plays, which is 23rd in the nation. The Gamecocks are surrendering 4.5 points per contest, which puts them 2nd in the nation."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Mississippi State vs South Carolina picks, predictions for Week 3 game
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