Who will win the Detroit Lions vs New Orleans Saints NFL Week 1 game Sunday?
The New Orleans Saints and Detroit Lions play on Sept. 13, at the Lions' Ford Field in a game on the NFL Week 1 schedule.
What do NFL Week 1 odds say about the Sunday game? Who are NFL Week 1 predictions and NFL Week 1 picks taking in the game?
Which team has the best chance to win the game according to NFL Week 1 win probabilities
?Check out The Arizona Republic's score prediction for the Sunday football game, as well as Saints vs Lions picks, odds and win chances for the NFL Week 1 game, which can be seen at 10 a.m. MST on FOX (stream with FUBO).
NFL Week 1 picks: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills
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Detroit Lions vs New Orleans Saints prediction
The Arizona Republic is predicting a 33-20 win for the Lions over the Saints in the NFL Week 1 Sunday football game.
Jeremy Cluff writes: "This Lions team is kind of flying under the radar in preseason Super Bowl odds, but Jared Goff and company still have firepower on offense, as the Saints will find out."
New Orleans Saints vs Detroit Lions picks
Will the Lions or Saints win the game in NFL Week 1?
Bookies.com says to bet the Saints with the points against the Lions.
Sports Betting Dime's formula predicts a 25.8-16.6 win for the Lions over the Saints.
Dimers.com's final score prediction? Lions 29, Saints 22.
BetMGM is predicting that the Lions will score more than 30.5 points against Saints.
Detroit Lions vs New Orleans Saints win probabilities
The Lions have a 71.9% chance to beat the Saints on Sunday, according to ESPN.
The site gives the Saints a 27.9% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
New Orleans Saints vs Detroit Lions odds
The Lions are a 7-point favorite over the Saints in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.
Detroit is -300 on the moneyline, while New Orleans is +250.
The over/under (point total) is set at 50.5 points.
NFL Week 1 odds: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | Point spreads, moneylines, over/unders
NFL's highest paid players in 2026: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Lions vs Saints predictions, picks, odds for NFL Week 1 game Sunday
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