Patrick Mahomes and the Kansas City Chiefs look to build off an impressive start to the season when they host the Indianapolis Colts on Sunday Night Football.
The Chiefs routed their divisional rivals from Denver in the opener, which marked Mahomes' successful return from the knee injury that prematurely ended his 2025 campaign. Indianapolis was handled by Baltimore in its opener when its defense was shredded by Lamar Jackson.
If that all sounds like Kansas City should be a big home favorite, yes it is, by 6.5 points as it looks to go 2-0.
What time is Sunday Night Football?
The Monday Night Football game between the Indianapolis Colts
at the Kansas City Chiefs starts at 6:20 p.m. MT/8:20 p.m. CT Sunday, Sept. 20, from Arrowhead Stadium in Kansas City. It will be televised on NBC and stream on Peacock.
Sunday Night Football: Colts at Chiefs
The Sunday Night Football game between the Kansas City Chiefs and Indianapolis Colts will be televised on NBC and streamed on Peacock.
TV: NBC and Peacock.
Broncos at Chiefs odds
From BetMGM.com
Kansas City Chiefs -6.5. Over-under 46.5. Kansas City is -285 on the money line; Indianapolis is +230.
Broncos vs Chiefs prediction
The line: Kansas City Chiefs 27, Indianapolis Colts 20.
With a line of 6.5 and an over-under of 46.5, the Chiefs are expected to win 27-20 or 26-20.
The Arizona Republic: Chiefs 27, Colts 20
Jeremy Cluff writes: "The Chiefs will be on a short week for this game after playing on Monday Night Football in NFL Week 1. It won't matter."
Bookies.com: Bet the Chiefs to cover vs Colts
Bill Speros writes: "Taylor, Travis and Patrick opened their season Monday night against the Denver Broncos. Indianapolis, meanwhile, had no answers on defense for Lamar Jackson, Derrick Henry and the Ravens Sunday. The Colts won't be able to crack the code when it comes to stoppng a healthy Patrick Mahomes at Arrowhead, either. Offensively, Daniel Jones remains Daniel Jones until further notice. Jonathan Taylor can’t carry this team by himself. Lock this one in before it moves north of touchdown."
Sports Betting Dime: Colts 21, Chiefs 20.8
The site's formula predicts that the Colts will win the NFL Week 2 game against the Chiefs.
ESPN: Chiefs have a 69.7% chance to beat Colts
The site gives the Colts a 30.1% shot at winning the NFL Week 2 game, with the remaining percentage accounting for a tie.
Dimers: Chiefs 26, Colts 20
It writes: "The numbers give the Colts a win probability of 30.0%, while the Chiefs have a win probability of 70.0%."
Bret Bloomquist can be reached at bbloomquist@elpasotimes.com; @Bretbloomquist on X.
This article originally appeared on El Paso Times: What time is the NFL game tonight? Colts at Chiefs odds, prediction
