The Buffalo Bills will be back in Sin City for the first time since 2020, when they take the field Sunday, Oct. 18, at Allegiant Stadium to play the Las Vegas Raiders.
Buffalo is coming off its most impressive win of the season, beating the potent Los Angeles Rams in overtime, 37-34, in a Monday Night Football classic where win probabilities swung to and fro like the doors of an Old West saloon.
The Raiders come into the game after a 45-17 loss to the New England Patriots led by QB Drake Maye.
Even with the short week, Josh Allen and the Bills are the early favorites among NFL analysts.
Bills vs. Rams odds
(Odds as of Tuesday afternoon)
- The Bills are 5-point favorites.
- The over/under is 53 points.
- The money line for the Bills is -235 (bet $235 to win $100) and the Raiders are +130 (bet $100 to win $195).
AZCentral.com: Bills 31, Raiders 21
Jeremy Cluff writes: "Josh Allen and the Bills will have a short week after playing on Monday Night Football in NFL Week 5, while Kirk
Cousins and the Raiders look to stop a 2-game skid. This game is in Las Vegas, but Buffalo will feel right at home, getting an essential victory."
Sports Illustrated: Raiders offense won't be able to keep up
Iain MacMillin writes: "I think I was right about the Raiders when I picked the Patriots last week. This is a team that got off to a hot start, but not one we should view as legitimate contenders. Their defense is a decent unit, but they still are one of the worst rushing offenses in the league, and since they can't run the ball, they have to rely on Kirk Cousins' arm, which is going to work far less often than it did the first four weeks of the season.
"The Raiders' offense won't be able to keep pace with Josh Allen and the Bills' offense. I'm happy to lay the points with the spread set below the magic number of seven."
Pick: Bills -6 (-110)
Bookies.com: Bet Bills to cover vs. Raiders
Bill Speros writes: "Las Vegas got shredded for 45 points by an injury-decimated Patriots offense last week. Josh Allen and the Bills have a great get-right spot in Sin City against a Raiders defense that's shown little resistance."
Didn't flinch. 😤#GoBills | #BillsMafia pic.twitter.com/xEYvaSnZLE
— Buffalo Bills (@BuffaloBills) October 13, 2026
Sports Betting Dime: Bills 33.1, Raiders 30.9
Sports Betting Dime predicts the Bills will win the NFL Week 6 game against the Raiders.
ESPN: Bills likely to win
ESPN Analytics gives Buffalo a 72.7% shot of winning the game.
Nothing better than a smiley @JoshAllenQB 😄 pic.twitter.com/jhftIfbV31
— NFL (@NFL) October 13, 2026
Dimers: Bills 30, Raiders 23
The Dimers site gives the Bills a win probability of 72.3%, while the Raiders have a win probability of 27.7%.
Bill Wolcott is a producer who helps cover the Buffalo Bills, high school and Rochester sports in general. The lifelong New Yorker has been a journalist for 32 years.
This article originally appeared on Rochester Democrat and Chronicle: Early Bills vs. Raiders predictions agree on who wins in Vegas
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