Who plays 'Thursday Night Football'? How to watch the Week 2 game

Get ready, football fans! "Thursday Night Football" is back. The first game of Week 2 of the NFL regular season kicks off Thursday night. Here's what to know about the game, including who's playing and how to watch. Who plays 'Thursday Night Football'? The Detroit Lions (1-0) travel to Highmark Stad

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What is the story about?

Get ready, football fans! "Thursday Night Football" is back.

The first game of Week 2 of the NFL regular season kicks off Thursday night.

Here's what to know about the game, including who's playing and how to watch.

Who plays 'Thursday Night Football'?

The Detroit Lions (1-0) travel to Highmark Stadium to take on the Buffalo Bills (1-0) for a Week 2 "Thursday Night Football" matchup.

Buffalo Bills quarterback Josh Allen (17) jogs on the field during the game against the Houston Texans at Reliant Stadium.

Lions vs. Bills kickoff time

Start time: 8:15 p.m. ET.
Date: Thursday, Sept. 17.

Detroit Lions running back Jahmyr Gibbs (0) celebrates first down against Chicago Bears during the second half at Ford Field in Detroit on Sunday, Sept. 14, 2025.

The Lions vs. Bills game starts at 8:15 p.m. at Highmark Stadium in Orchard Park, New York.

What channel is 'Thursday Night Football' on?

TV channel: ABC and FOX (for in-market viewers).
Live stream: Prime and NFL+.

Amazon Prime Video is hosting "Thursday Night Football" for the fifth NFL season. New Amazon Prime Video users can sign up for a 30-day free trial to stream the game.

Aug 23, 2019; Detroit, MI, USA; Buffalo Bills quarterback Josh Allen (17) passes the ball during the first quarter against the Detroit Lions at Ford Field. Mandatory Credit: Raj Mehta-USA TODAY Sports

ABC and FOX will also simulcast the game locally. Lions vs. Bills airs on WJBK-TV (channel 2) in Detroit and WKBW-TV (channel 7) in New York.

Who is announcing the Lions vs. Bills game?

Al Michaels

is the play-by-play announcer, Kirk Herbstreit is the analyst and Kaylee Hartung is the sideline reporter.

Other hosts and analysts include Charissa Thompson, Andrew Whitworth, Richard Sherman, Ryan Fitzpatrick, Tony Gonzalez, Taylor Rooks and Terry McAulay.