What's Happening?
Bio-Techne and Refeyn have announced a new partnership to develop an integrated workflow for the characterization of bispecific antibodies and biosimilars. This collaboration combines Bio-Techne’s MauriceFlex imaged capillary isoelectric focusing (icIEF)
fractionation system with Refeyn’s TwoMP mass photometry platform. The new workflow allows researchers to correlate charge heterogeneity with molecular weight and aggregation at a single-molecule resolution within four hours. This advancement addresses the challenges in characterizing bispecific antibodies, which are structurally complex and difficult to analyze. The integrated system aims to streamline the characterization process, reducing the need for multiple tests and supporting more efficient development.
Why It's Important?
The development of this integrated workflow is significant for the biopharmaceutical industry, particularly in the field of antibody therapeutics. Bispecific antibodies represent a rapidly growing segment within next-generation antibodies, but their complexity poses challenges in characterization, which can delay development and increase manufacturing risks. By enabling a more comprehensive analysis of charge and size variants, the new workflow can help reduce these risks, control costs, and improve decision-making in the early stages of development. This innovation could accelerate the development of new therapies and enhance the efficiency of biopharmaceutical research and production.
