Niacinamide's Role
Niacinamide, a vitamin B, inhibits melanosome transfer, reducing skin pigmentation. However, as Dr. Ameesha Mahajan explains, it doesn't directly tackle
tyrosinase, the enzyme responsible for melanin production. While 4–5% use for 8–12 weeks may show improvement, it's often not enough alone, especially for deeper spots. It has its limitations.
Beyond Niacinamide Alone
For significant results, dermatologists often recommend a multi-agent approach. This involves adding ingredients to work synergistically. Combining ingredients can enhance penetration and target different aspects of pigmentation. Let's explore some of these powerful additions to your skincare routine for better results.
Tretinoin's Power Unveiled
Tretinoin boosts epidermal turnover, promoting the shedding of pigmented cells, and boosts the effectiveness of other ingredients. This helps to remove existing dark spots by speeding up the process of skin cell renewal. This action also helps other actives in the formula to penetrate deeper.
Kojic & Arbutin Magic
Kojic acid (1-2%) hinders melanin synthesis. Arbutin (2-5%), a safer hydroquinone derivative, also inhibits tyrosinase. Both these ingredients can directly target melanin production, complementing niacinamide's action. Consider incorporating these into your routine for a stronger impact on dark spots.
Tranexamic Acid's Benefit
Tranexamic acid disrupts the interaction between skin cells and melanocytes. It lowers inflammatory mediators, and may interfere with tyrosinase activity. It is important to disrupt several pathways involved in hyperpigmentation for optimal results. Always consult a dermatologist for personalized advice.
