3 Dead As Large UPS Cargo Plane Crashes, Bursts Into Flames During Takeoff In Louisville | Videos

A UPS cargo plane with three people aboard crashed and exploded early on Wednesday while taking off from an airport in Louisville, Kentucky. All on board were dead, while 11 others were injured.

According

to the Associated Press, the plane crashed about 5.15 pm (US local time) as it was departing for Honolulu from Louisville’s Muhammad Ali International Airport.

The plane lifted slightly off the ground before crashing and exploding in a huge fireball, it was known.

NEW: Security camera shows UPS Flight 2976 crashing in Louisville, Kentucky pic.twitter.com/YtXRSvCzSA

— BNO News (@BNONews) November 5, 2025

Videos of the plane crash showed flames on the plane’s left wing and a trail of smoke.

Heartbreaking images coming out of Kentucky tonight.

Here’s an update from @FAANews
– UPS cargo flight 2976
– Crashed around 5:15 ET after takeoff from Louisville Muhammad Ali International Airport en route to Honolulu
– The aircraft was a McDonnell Douglas MD-11.

Please… pic.twitter.com/yE1Brhv8cQ

— Secretary Sean Duffy (@SecDuffy) November 4, 2025

Kentucky Governor Andy Beshear told a press briefing that he expected the number of dead and injured was going to rise, with the current toll including only those on the ground that were currently accounted for.

Meanwhile, UPS said in a statement that three crew members were on board the aircraft, adding that “we have not confirmed any injuries/casualties.”

Mayor Craig Greenberg told WLKY-TV that fuel on the plane was an “extreme reason for concern in so many different ways”.

The cause of the crash was under investigation by the FAA and the US National Transportation Safety Board (NTSB).

UPS’s largest package handling facility is in Louisville. The hub employs thousands of workers, has 300 daily flights and sorts more than 400,000 packages an hour.

A shelter-in-place order was extended to all areas north of the airport to the Ohio River.

The Louisville airport is only a 10-minute drive from the city’s downtown, which sits on the river bordering the Indiana state line. There are residential areas, a water park and museums in the area.

The McDonnell Douglas MD-11 airplane owned by UPS was manufactured in 1991.

ALSO READ | 6 Killed After Military Chopper Deployed For Typhoon Relief Ops Crashes In Philippines