Kris Jenner Reveals Why She Quit Ozempic, Claims It Made Her 'So Sick'

Have you ever wondered whether the promise of rapid weight loss is worth the physical toll it can take on the body? Kris Jenner’s candid admission has brought that question into sharp focus.

The Kardashian-Jenner family matriarch recently opened up about her early experience with Ozempic on the SheMD podcast. She revealed that she tried the GLP-1 medication when it was still relatively unknown in Hollywood. Jenner recalled experiencing severe nausea that left her so unwell she was unable to work.

“It made me really sick,” Jenner shared. “I called her up one day and I go, ‘I can’t work anymore. I can’t, I’m so sick. I’m like, nauseous.’”

How Did Kris Jenner Use Ozempic To Lose Weight?

Jenner was widely speculated to be among the earliest Hollywood celebrities associated with the rapid rise of

GLP-1 weight-loss medications. She later revealed that she stopped using Ozempic and explored other wellness options, including peptide injections and supplements, which she described as a “game changer” for her energy levels and overall wellbeing.

Injectable peptides, which are short chains of amino acids, have become increasingly popular in recent years for claims linked to weight loss, muscle building and improved athletic performance, according to the American Medical Association. However, experts warn that many of these peptides have not been studied thoroughly, and their use may trigger side effects ranging from digestive discomfort to more serious complications such as pancreatitis.

Jenner described the peptide supplements as a major turning point for her overall energy levels and daily routine. She shared that the treatment helped her stay active for longer hours, especially given her demanding schedule and early mornings.

“That was a game changer,” Jenner said, explaining that the peptides gave her a few extra productive hours in the evening instead of feeling completely drained by the end of the day. She added that the supplements also benefited her hair, skin and nails, while boosting her energy levels significantly.

The reality star also addressed the attention surrounding her widely discussed facelift, which became a viral talking point in 2025.

Why Ozempic Is Everywhere Right Now

Originally developed to help manage Type 2 Diabetes, Ozempic belongs to a class of medications known as GLP-1 receptor agonists. These drugs work by regulating appetite, slowing digestion and helping stabilise blood sugar levels.

The most commonly reported symptoms remain gastrointestinal: nausea, vomiting, constipation, diarrhoea and abdominal discomfort. According to Harvard Health, these side effects are particularly common during dose increases.

Ozempic Face, Ozempic Butt: The Viral Side Effects of the Weight Loss Drug

Terms like “Ozempic face”, “Ozempic butt”, “Ozempic hands”, “Ozempic feet” and even “Ozempic mouth” now circulate widely online. Most are not official medical diagnoses, but rather internet-created descriptions of visible body changes linked to sudden fat loss.

“Ozempic face” generally refers to a gaunter facial appearance caused by rapid fat reduction, often leading to sagging skin, deeper wrinkles or hollow cheeks. Harvard Health notes that these effects are not unique to Ozempic itself and can occur with any rapid weight loss.

Meanwhile, online discussions around “Ozempic butt” describe loose skin or volume loss in the hips and lower body following significant weight reduction. Reddit users across GLP-1 communities have openly discussed changes in skin elasticity and muscle tone during rapid weight loss journeys.

“Ozempic vulva,” in particular, has gained attention on social media. The term describes a sagging or deflated appearance in the labia caused by rapid loss of fatty tissue, along with possible dryness and changes in comfort. While not an official medical diagnosis, these changes reflect how sudden and significant weight loss can affect skin elasticity and body composition across different areas of the body.