What's Happening?
Courtney Hazelton-Harrington, a senior R&D scientist at Lonza Biologics, has conducted a study on process intensification in biomanufacturing. The study highlights the role of high-throughput analytical technologies in enhancing productivity, efficiency, and sustainability. Process analytical technology (PAT) provides real-time data on critical process parameters, enabling better control and faster analysis. Hazelton-Harrington collaborated with Sartorius to test Raman spectroscopy in downstream processes, showing promising results in monitoring protein and excipient concentrations.
Why It's Important?
The study underscores the importance of process intensification in biomanufacturing, which aims to produce more products using fewer resources. By integrating advanced analytical technologies, companies can improve process efficiency and reduce costs. This innovation is crucial for the biopharmaceutical industry, which faces increasing demand for high-quality products. Enhanced analytical capabilities can lead to faster development and scaling of manufacturing processes, benefiting both producers and consumers.
What's Next?
The successful application of Raman spectroscopy in downstream processes may lead to broader adoption of inline PAT technologies in biomanufacturing. Companies may invest in developing robust models to monitor additional quality attributes, potentially transforming traditional batch operations into continuous processes. This shift could drive further innovation in analytical technologies, fostering collaboration between technology suppliers and biomanufacturers.
Beyond the Headlines
The study highlights the potential for process intensification to revolutionize biomanufacturing. It suggests a shift towards continuous operations, which could reduce environmental impact and improve sustainability. The collaboration between Lonza Biologics and Sartorius exemplifies the importance of partnerships in driving technological advancements.
