What's Happening?
An international team of scientists has discovered a biological process that allows pancreatic cancer to grow undetected by the immune system. The study, published in the journal Cell, reveals that the protein
MYC, known for promoting cell division, also helps tumors evade immune detection by binding to RNA molecules and forming molecular condensates. These condensates prevent the immune system from recognizing the tumor as a threat. The research, led by Martin Eilers and supported by Cancer Grand Challenges, suggests that targeting MYC's RNA-binding function could expose tumors to immune attack without affecting its role in cell growth.
Why It's Important?
This discovery provides a new target for cancer therapies, particularly for aggressive cancers like pancreatic cancer. By focusing on MYC's ability to hide tumors from the immune system, researchers can develop treatments that enhance immune recognition without disrupting normal cell functions. This approach could lead to more effective and less toxic cancer treatments. The study also highlights the importance of international collaboration in tackling complex cancer challenges, as it brings together diverse expertise and resources to accelerate scientific progress.
