What's Happening?
A recent webinar hosted by Genetic Engineering and Biotechnology News focused on strategies for removing double-stranded RNA (dsRNA) impurities and improving quantitation in emerging mRNA modalities. As
mRNA-based therapeutics expand beyond vaccines to include various applications, the need for consistent purity and quality in manufacturing has become critical. The webinar featured insights from Kelsey Swingle, PhD, an assistant professor at Rice University, and Nathaniel Clark, PhD, a senior scientist at Repligen. They discussed new purification and quantitation techniques, including the use of dsRNA-specific affinity chromatography resin and in-line variable pathlength technology, which aim to enhance the accuracy and efficiency of mRNA therapeutic production.
Why It's Important?
The removal of dsRNA impurities is essential for the safety and efficacy of mRNA therapeutics, as these byproducts can trigger unwanted immune responses. The development of advanced purification methods is crucial for the pharmaceutical industry, particularly as mRNA technologies are applied to a broader range of treatments beyond COVID-19 vaccines. Accurate quantitation of mRNA is also vital for ensuring the correct dosage and effectiveness of these therapies. The webinar highlights the ongoing efforts to refine manufacturing processes, which could lead to more reliable and scalable production of mRNA-based treatments, benefiting both manufacturers and patients.
What's Next?
The adoption of these emerging techniques could significantly impact the production of mRNA therapeutics. As the industry continues to evolve, manufacturers may increasingly implement these methods to meet the growing demand for high-quality mRNA products. The insights shared in the webinar could guide future research and development efforts, potentially leading to further innovations in mRNA purification and quantitation. Continued collaboration between academia and industry will be essential to address the challenges and opportunities in this rapidly advancing field.
