What's Happening?
Researchers have developed a single-copy optogenetic system for Streptomyces, a genus of bacteria known for its role in natural product synthesis. This new system, called iLiEX-i, integrates light-inducible
expression modules into the genome, allowing for the controlled production of valuable enzymes. The system uses a light sensor and transcriptional amplification modules to regulate gene expression in response to blue-green light. This innovation addresses previous limitations of plasmid-based systems, such as host range restrictions and plasmid loss. The iLiEX-i system has demonstrated high-level production of enzymes like leucine aminopeptidase and transglutaminase, which are important in industrial applications.
Why It's Important?
The development of the iLiEX-i system represents a significant advancement in the field of synthetic biology and biotechnology. By enabling precise control over gene expression in Streptomyces, this system can enhance the production of industrially relevant enzymes, potentially reducing costs and increasing efficiency in biomanufacturing processes. The ability to produce high yields of enzymes with minimal genetic modification could lead to more sustainable and scalable production methods. This system also broadens the potential applications of Streptomyces in various industries, including pharmaceuticals, agriculture, and food processing, by facilitating the production of complex natural products.
