What is the story about?
What's Happening?
DemeRx, Inc., a clinical-stage biopharmaceutical company, has been awarded a $1.7 million Small Business Innovation Research Grant from the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health. This funding is intended to support the advancement of DMX-1001, a neuroplastogen drug candidate, through necessary studies and into Phase 2 clinical trials for treating Alcohol Use Disorder (AUD). DMX-1001, also known as noribogaine, targets multiple areas of the central nervous system and promotes neuroplasticity, aiming to reduce cravings and the compulsion to drink. The drug has shown promise in Phase 1 clinical trials, where it was found to be safe and well-tolerated.
Why It's Important?
Alcohol Use Disorder affects over 29 million Americans and is a leading cause of preventable death. Current therapeutic options are limited, with high relapse rates among those treated. The development of DMX-1001 represents a potentially transformative approach to treating AUD by addressing the neurological underpinnings of the disorder. If successful, this drug could significantly reduce the burden of AUD on individuals and healthcare systems by offering a more effective treatment option. The NIH grant not only validates DemeRx's approach but also highlights the urgent need for innovative solutions in addiction therapeutics.
What's Next?
Following the completion of Phase 1b clinical trials, DemeRx plans to use the results to inform the target dose selection for Phase 2 trials involving patients with AUD. The progression to Phase 2 trials will be crucial in determining the drug's efficacy in a larger patient population. The outcomes of these trials could influence future funding and partnerships, as well as regulatory decisions regarding the drug's approval and commercialization.
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