What's Happening?
Recent discussions have emerged regarding the safety and side effects of statins, particularly concerning liver and kidney health. Experts have clarified that serious liver or kidney problems from statins are uncommon. Statins are considered safe for individuals with fatty liver disease or compensated cirrhosis, and should not be withheld when heart benefits are expected. Randomized evidence shows no clear increase in acute kidney injury with regular statin use. However, a large observational study linked high-dose rosuvastatin to small increases in hematuria or proteinuria, especially in advanced chronic kidney disease (CKD). This highlights the importance of careful dosing in such patients.
Why It's Important?
Statins are widely prescribed for cholesterol management and cardiovascular health, making their safety profile crucial for public health. Misconceptions about statin intolerance can lead to unnecessary avoidance, potentially increasing cardiovascular risk. Understanding the true risks and benefits allows healthcare providers to make informed decisions, ensuring patients receive the heart-protective benefits of statins without undue concern over liver or kidney damage. This clarity is particularly important for patients with chronic kidney disease, who are at higher cardiovascular risk and can benefit from statin therapy.
