What's Happening?
Genentech has announced positive results from its Phase III IMvigor011 study, which evaluated Tecentriq (atezolizumab) as an adjuvant treatment for muscle-invasive bladder cancer (MIBC) patients at risk of recurrence post-surgery. The study utilized a ctDNA-guided
approach, using Natera’s Signatera ctDNA Molecular Residual Disease test, to identify patients who could benefit from Tecentriq. The results showed a 41% reduction in the risk of death and a 36% reduction in the risk of disease recurrence or death compared to placebo. These findings were presented at the European Society for Medical Oncology Congress 2025 and are set to be discussed with health authorities, including the U.S. Food and Drug Administration.
Why It's Important?
The study's findings are significant as they highlight the potential of ctDNA-guided treatment to personalize cancer therapy, sparing patients at low risk of recurrence from unnecessary treatment and its associated side effects. This approach could revolutionize the treatment of MIBC, a cancer type with historically poor long-term outcomes. By combining precision diagnostics with immunotherapy, healthcare providers can tailor treatments more effectively, potentially improving patient outcomes and reducing healthcare costs associated with overtreatment.
What's Next?
The results will be discussed with health authorities, including the FDA, which could lead to regulatory approval and broader adoption of ctDNA-guided treatment in clinical practice. This could pave the way for similar approaches in other cancer types, further advancing personalized medicine.
