What is the story about?
What's Happening?
Eli Lilly and Company announced positive results from its ACHIEVE-3 Phase 3 clinical trial, which evaluated the efficacy and safety of orforglipron compared to oral semaglutide in adults with type 2 diabetes. The trial involved 1,698 participants and demonstrated that orforglipron, at both 12 mg and 36 mg doses, significantly lowered A1C levels and promoted weight loss more effectively than oral semaglutide. Participants taking the highest dose of orforglipron lost an average of 19.7 lbs, compared to 11.0 lbs with oral semaglutide. The trial also showed improvements in cardiovascular risk factors such as non-HDL cholesterol and systolic blood pressure.
Why It's Important?
The results of the ACHIEVE-3 trial suggest that orforglipron could become a foundational treatment for type 2 diabetes, offering superior glycemic control and weight loss benefits compared to existing treatments. This could have significant implications for diabetes management, potentially improving patient outcomes and reducing healthcare costs associated with diabetes-related complications. The success of orforglipron in this trial may also bolster Eli Lilly's position in the competitive diabetes treatment market, providing a new option for patients inadequately controlled with current therapies.
What's Next?
Eli Lilly plans to submit orforglipron for regulatory approval in 2026, following further analysis and presentation of the trial data at upcoming medical meetings. The company is also conducting additional Phase 3 studies to explore orforglipron's potential in weight management and other conditions such as obstructive sleep apnea and hypertension. These efforts could expand the drug's application beyond diabetes, potentially addressing multiple health issues associated with obesity and metabolic disorders.
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