Researchers Find OTC Nasal Spray Reduces COVID-19 Infections by 67% in Trial

What's Happening?

A recent study conducted by researchers at Germany's Saarland University has found that a generic antihistamine nasal spray, azelastine, may significantly reduce COVID-19 infections. The Phase 2 trial, which was randomized, double-blind, and placebo-controlled, involved 450 healthy adults. Participants used the nasal spray three times daily over a period of 56 days. Results showed that only 2.2% of those using the spray contracted COVID-19, compared to 6.7% in the placebo group, indicating a 67% reduction in infections. Additionally, those who did contract the virus while using the spray tested positive for a shorter duration than those in the placebo group. The study also noted fewer respiratory infections overall among the spray users, suggesting a potential general antiviral mechanism.

Why It's Important?

The findings of this study could have significant implications for public health, particularly in the ongoing management of COVID-19. If further trials confirm the efficacy of azelastine nasal spray, it could become a widely accessible preventive measure against COVID-19, especially given its over-the-counter availability in the U.S. This could reduce the burden on healthcare systems and provide an additional tool in the fight against the pandemic. Moreover, the potential antiviral properties against other respiratory viruses could broaden its use beyond COVID-19, offering a simple and cost-effective method to enhance respiratory health.

What's Next?

Further research is needed to confirm the efficacy of azelastine nasal spray in larger trials. If successful, regulatory bodies may consider endorsing its use as a preventive measure against COVID-19. Healthcare providers and policymakers will likely monitor these developments closely, as they could influence public health strategies and recommendations. Additionally, the pharmaceutical industry may explore the development of similar products with enhanced antiviral properties.