What's Happening?
Two studies have highlighted the role of immune cell energy metabolism in the progression of atherosclerosis. Researchers found that macrophages, key immune cells in artery walls, require the amino acid glutamine to function effectively. A deficiency
in glutamine uptake leads to larger, unstable plaques, increasing the risk of heart attacks and strokes. The studies, involving international collaboration, suggest that supporting macrophage metabolism could stabilize plaques and prevent cardiovascular events. New diagnostic tools, including PET imaging and blood tests, are being developed to identify high-risk plaques.
Why It's Important?
These findings could revolutionize the approach to diagnosing and treating atherosclerosis, a leading cause of heart attacks and strokes. By understanding the metabolic needs of macrophages, new therapies could be developed to stabilize arterial plaques, potentially reducing the incidence of cardiovascular events. The research also paves the way for more precise diagnostic tools, which could lead to earlier intervention and better patient outcomes. This represents a significant advancement in cardiovascular medicine, with implications for public health and healthcare costs.
