What is the story about?
What's Happening?
Researchers at the University of Texas MD Anderson Cancer Center have published a study in Nature Metabolism indicating that the glucose-fructose mix found in sugary drinks may directly fuel metastasis in advanced colorectal cancer. The study, led by Jihye Yun, Ph.D., assistant professor of Genetics, utilized laboratory cancer models to compare the effects of sugary drinks with those of glucose or fructose alone. The findings revealed that only the sugar mix enhanced the mobility of cancer cells, leading to faster spread to the liver, a common site for colorectal cancer metastasis. The sugar mix was found to activate an enzyme called sorbitol dehydrogenase (SORD), which boosts glucose metabolism and triggers the cholesterol pathway, driving metastasis. Blocking SORD slowed metastasis even in the presence of the sugar mix, suggesting potential therapeutic strategies.
Why It's Important?
This study highlights the significant impact of diet on cancer progression, particularly in advanced colorectal cancer. The findings suggest that reducing sugary drink consumption or targeting the SORD enzyme could potentially benefit patients by slowing metastasis. The research challenges previous assumptions that sugar's link to cancer was primarily through obesity, showing direct effects on tumor growth and spread. These insights could lead to changes in dietary recommendations for cancer patients, emphasizing the reduction of sugary drinks. The study also opens avenues for repurposing statins, common heart drugs, to inhibit the cholesterol pathway involved in metastasis.
What's Next?
Further clinical investigations are needed to confirm these findings outside of preclinical models. The study suggests potential revisions to dietary guidelines for cancer patients, particularly those with colorectal cancer, to reduce sugary drink consumption. Researchers may explore the repurposing of statins to target the cholesterol pathway activated by sugary drinks. Additionally, the study calls for more research into the role of diet in cancer progression, potentially influencing public health policies and cancer treatment protocols.
Beyond the Headlines
The study raises ethical considerations regarding the marketing and consumption of sugary drinks, especially among vulnerable populations such as cancer patients. It underscores the need for greater awareness and education on the dietary factors influencing cancer progression. The findings may also prompt discussions on regulatory measures to limit sugary drink consumption and promote healthier alternatives.
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