What's Happening?
Researchers from MIT and Harvard Medical School are exploring the phenomenon where autism symptoms appear to ease during a fever. This 'fever effect' has been observed by parents and caregivers, and the research team, supported by a $2.1 million grant
from the Marcus Foundation, aims to understand the underlying biology. Neuroscientist Gloria Choi and immunologist Jun Huh have conducted a decade of research in mice, identifying an immune-signaling molecule, IL-17a, that seems to calm overactive brain circuits during infections. Their findings suggest that the improvement in symptoms is linked to this molecule rather than the fever itself. The team plans to create a biobank of blood and stool samples from volunteers to further investigate these markers in humans.
Why It's Important?
This research could lead to new therapeutic approaches for managing autism spectrum disorders. By understanding the biological mechanisms behind the 'fever effect,' scientists hope to develop treatments that can mimic these effects without the need for an actual fever. This could significantly improve the quality of life for individuals with autism and their families. The study also highlights the potential of immune system interactions in neurological conditions, opening new avenues for research and treatment in related disorders.
