What's Happening?
A study presented at the American Heart Association’s Scientific Sessions 2025 has raised concerns about the long-term use of melatonin in adults with chronic insomnia. The research, involving over 130,000 participants, found that those using melatonin for
a year or more had a higher likelihood of heart failure and increased mortality rates compared to non-users. The study, led by Ekenedilichukwu Nnadi from SUNY Downstate, suggests that melatonin, often considered a natural and harmless sleep aid, may pose significant health risks. The findings call for caution and further rigorous trials to assess the safety of melatonin supplements.
Why It's Important?
The study's findings challenge the common perception of melatonin as a safe sleep aid, highlighting potential risks for heart failure and increased mortality. With heart failure affecting millions of U.S. adults, these results could influence prescribing practices and patient counseling regarding sleep aids. The research underscores the need for careful documentation of supplement use and consideration of alternative insomnia treatments, such as cognitive behavioral therapy. As melatonin is widely available over-the-counter, the study emphasizes the importance of informed decision-making by both healthcare providers and patients.
What's Next?
Further research is needed to explore the relationship between melatonin use and heart health, including randomized trials to establish causation. The study's authors plan to conduct more detailed analyses considering dosage, formulations, and adherence. Healthcare providers may need to revise their approach to insomnia treatment, prioritizing evidence-based therapies over long-term pharmacologic aids. Public awareness campaigns could also be initiated to educate consumers about the potential risks of chronic melatonin use.
Beyond the Headlines
The study highlights broader issues related to the regulation of dietary supplements in the U.S., where melatonin is sold over-the-counter without stringent oversight. This raises questions about the safety and efficacy of other supplements marketed as natural remedies. The findings may prompt discussions on the need for more comprehensive regulatory frameworks to ensure consumer safety. Additionally, the study could lead to increased interest in non-pharmacological approaches to insomnia, promoting healthier sleep habits and lifestyle changes.
