What's Happening?
CryoTherapeutics, a Belgian medical device company, has announced a collaboration with SpectraWAVE and the Cardiovascular Research Foundation (CRF) to launch the ICECAP clinical study. This study aims
to stabilize high-risk coronary plaques using a novel cryotherapy system. The approach involves cooling plaques to temperatures between -10 to -20°C to reduce inflammation and increase fibrous-cap thickness, potentially lowering the risk of myocardial infarction. The study will utilize advanced intravascular imaging techniques, including Near-Infrared Spectroscopy (NIRS) and Optical Coherence Tomography (OCT), to assess the biological effects of cryotherapy over time. The ICECAP study is set to begin patient recruitment in early 2026 across multiple centers in Belgium and the UK.
Why It's Important?
The ICECAP study represents a significant advancement in the treatment of coronary artery disease, which is a leading cause of death worldwide. By targeting non-obstructive high-risk plaques, the study could offer a new therapeutic option that avoids the use of foreign materials like stents. This approach has the potential to improve patient outcomes by preventing plaque rupture and subsequent myocardial infarction. The collaboration with SpectraWAVE and CRF brings together expertise in imaging and cardiovascular research, enhancing the study's potential to generate impactful results. Success in this study could pave the way for broader adoption of cryotherapy in cardiology, offering a safer and more effective treatment for high-risk patients.
What's Next?
The ICECAP study will be conducted over several months, with initial results expected to be shared at major scientific meetings as data mature. The study's findings could influence future clinical practices and guidelines for the treatment of coronary artery disease. If successful, CryoTherapeutics may seek regulatory approval for its cryotherapy system, potentially expanding its use in clinical settings. The collaboration partners are committed to advancing research in cardiovascular disease, and further studies may explore additional applications of cryotherapy in cardiology.
